Brivudine-Bromovinyldeoxyuridine-DataSheet-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEBrivudineCat. No.: HY-13578CAS No.: 69304-47-8Synonyms: Bromovinyldeoxyuridine; BVDU分式: CHBrNO分量: 333.14作靶点: CMV作通路: Anti-infection储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 330 mg/mL

2、(990.57 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 3.0017 mL 15.0087 mL 30.0174 mL5 mM 0.6003 mL 3.0017 mL 6.0035 mL10 mM 0.3002 mL 1.5009 mL 3.0017 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。BIOLOGICAL ACTIVITY物活性 Brivudine具有抗病毒活性的胸苷类似物,于治疗早期急性带

3、状疱疹。体外研究Brivudine is an analog of thymidine, and is incorporated into the viral DNA. It blocks the action of DNApolymerases, thus inhibiting viral replication. It has a stronger antiviral effect against the varicella-zoster viruscompared with reference compounds such as aciclovir or penciclovir 1. I

4、t has high, selective activity against1/2 Master of Small Molecules 您边的抑制剂师www.MedChemEvaricella zoster virus (VZV), inhibiting VZV replication, possibly through competitive inhibition of viral DNApolymerase, or by acting as an alternative substrate to deoxythymidine triphosphate, causing viral DNAs

5、trand breakage 2.体内研究 At a dose of 125 mg once daily, brivudine has proved to be superior to aciclovir with respect to reducing theperiod of new blister production, and has shortened the duration of post-herpetic neuralgia 1.REFERENCES1. Rabasseda X, et al. Brivudine: a herpes virostatic with rapid

6、antiviral activity and once-daily dosing. Drugs Today (Barc). 2003May;39(5):359-71.2. Keam SJ, et al. Brivudin (bromovinyl deoxyuridine). Drugs. 2004;64(18):2091-7; discussion 2098-9.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-