Darifenacin-hydrobromide-UK-88525-hydrobromide-DataSheet-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEDarifenacin hydrobromideCat. No.: HY-A0012CAS No.: 133099-07-7Synonyms: UK-88525 (hydrobromide)分式: CHBrNO分量: 507.46作靶点: mAChR作通路: GPCR/G Protein; Neuronal Signaling储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1

2、 month溶解性数据体外实验 DMSO : 33.33 mg/mL (65.68 mM; Need ultrasonic)H2O : 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (4.93 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (4.93 mM); Clear solution1/2 Master of Small Molecules 您边的抑制剂师www.MedChemE3. 请依序添

3、加每种溶剂： 10% DMSO 90% corn oilSolubility: 2.5 mg/mL (4.93 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 Darifenacin hydrobromide (UK-88525 hydrobromide)是选择性 M3 蕈毒碱受体拮抗剂，pKi 为 8.9。户使本产品发表的科研献 Br J Pharmacol. 2015 Dec;172(23):5619-33. Sci Rep. 2017 Jan 19;7:40802. Eur J Pharmacol. 2011 Aug 1;663(1-3):74-9.

4、Oncotarget. 2016 Apr 5;7(14):18085-94.See more customer validations on HYPERLINK / www.MedChemEREFERENCES1. Hegde SS, et al. Functional role of M2 and M3 muscarinic receptors in the urinary bladder of rats in vitro and in vivo. Br J Pharmacol,1997, 120(8), 1409-1418.2. Miller DW, et al. Evaluation o

5、f drug efflux transporter liabilities of darifenacin in cell culture models of the blood-brain and blood-ocularbarriers. Neurourol Urodyn, 2011, 30(8), 1633-1638.3. Iijima K, et al. Effects of the M3 receptor selective muscarinic antagonist darifenacin on bladder afferent activity of the rat pelvic nerve.Eur Urol, 2007, 52(3), 842-847.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 0