Dydrogesterone _Progesterone Receptor Agonist - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEDydrogesteroneCat. No.: HY-B0257ACAS No.: 152-62-5分式: CHO分量: 312.45作靶点: Progesterone Receptor作通路: Others储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 33.33 mg/mL (106.67 mM; Need ultrason

2、ic)Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 3.2005 mL 16.0026 mL 32.0051 mL5 mM 0.6401 mL 3.2005 mL 6.4010 mL10 mM 0.3201 mL 1.6003 mL 3.2005 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验 请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄清的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作液，建议您现现配，当天使；澄清的储备液可以根据储存条件，适当保存；以

3、下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (8.00 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (8.00 mM); Clear solution3. 请依序添加每种溶剂： 10% DMSO 90% corn oilSolubility: 2.5 mg/mL (8.00 mM); Clear s

4、olution1/2 Master of Small Molecules 您边的抑制剂师www.MedChemEBIOLOGICAL ACTIVITY物活性 Dydrogesterone服活性的孕激素，可作于孕酮缺乏相关疾病。IC50 & Target Progesterone Receptor 1.体外研究 Dydrogesterone is a potent, orally active progestogen indicated in a wide variety of gynaecological conditionsrelated to progesterone deficiency

5、. Although similar in molecular structure and pharmacological effects toendogenous progesterone. It is orally active at far lower doses. Its freedom from estrogenic, androgenic,anabolic, corticoid and other undesirable hormonal effects gives it additional benefits over most othersynthetic progestoge

6、ns.Dydrogesterone has also been registered as hormone replacement therapy (HRT) tocounteract the negative effects of unopposed estrogen on the endometrium in women with an intact uterus.Dydrogesterone is relatively safe and well tolerated, and does not exhibit the androgenic side effects that arecommon with some other progestins, like medroxyprogesterone 1.REFERENCES1. Dydrogesterone, From Wikipedia, the free encyclopediaMcePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.T