HC-067047 _TRP Channel Antagonist - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEHC-067047Cat. No.: HY-100208CAS No.: 883031-03-6分式: CHFNO分量: 471.51作靶点: TRP Channel作通路: Membrane Transporter/Ion Channel; Neuronal Signaling储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 5

2、0 mg/mL (106.04 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 2.1208 mL 10.6042 mL 21.2085 mL5 mM 0.4242 mL 2.1208 mL 4.2417 mL10 mM 0.2121 mL 1.0604 mL 2.1208 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验 请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄清的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作液

3、，建议您现现配，当天使；澄清的储备液可以根据储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (5.30 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (5.30 mM); Clear solution3. 请依序添加每种溶剂： 10% DMSO 90% corn oilSolubil

4、ity: 2.5 mg/mL (5.30 mM); Clear solution1/2 Master of Small Molecules 您边的抑制剂师www.MedChemEBIOLOGICAL ACTIVITY物活性 HC-067047种有效，选择性的 TRPV4 拮抗剂，抑制，TRPV4的IC50 分别为48 nM，133nM，17 nM。IC50 & Target IC50: 48 nM (human TRPV4), 133 nM (rat TRPV4), 17 nM (mouse TRPV4) 1户使本产品发表的科研献 Biomed Pharmacother. 2018 Dec;1

5、08:540-546.See more customer validations on HYPERLINK / www.MedChemEREFERENCES1. Everaerts W et al. Inhibition of the cation channel TRPV4 improves bladder function in mice and rats with cyclophosphamide-inducedcystitis.Proc Natl Acad Sci U S A. 2010 Nov 2;107(44):19084-9.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 021-