Grapiprant-CJ-023423-DataSheet-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEGrapiprantCat. No.: HY-16781CAS No.: 415903-37-6Synonyms: CJ-023423; RQ-00000007; AAT-007分式: CHNOS分量: 491.61作靶点: Prostaglandin Receptor作通路: GPCR/G Protein储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数

2、据体外实验 DMSO : 50 mg/mL (101.71 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 2.0341 mL 10.1707 mL 20.3413 mL5 mM 0.4068 mL 2.0341 mL 4.0683 mL10 mM 0.2034 mL 1.0171 mL 2.0341 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验请根据您的实验动物和给药式选择适当的溶解案，配制前请先配

3、制澄清的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作液，建议您现现配，当天使；澄清的储备液可以根据储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 3 mg/mL (6.10 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 3 mg/mL (6.10 mM); Clear solution1/2 Master

4、 of Small Molecules 您边的抑制剂师www.MedChemE3. 请依序添加每种溶剂： 10% DMSO 90% corn oilSolubility: 3 mg/mL (6.10 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 Grapiprant种选择性EP4受体拮抗剂, 理配体为前列腺素E2（PGE2）。户使本产品发表的科研献 JCI Insight. 2018 Feb 8;3(3). Xenobiotica. 2019 Feb;49(2):177-186. General Veterinary Medicine, Auburn Un

5、iversity. 2018 May.See more customer validations on HYPERLINK / www.MedChemEREFERENCES1. Vito VD, et al. Detection and quantification of the selective EP4 receptor antagonist CJ-023423 (grapiprant) in canine plasma by HPLCwith spectrofluorimetric detection. J Pharm Biomed Anal. 2016 Jan 25;118:251-8

6、.2. Rausch-Derra LC, et al. Evaluation of the safety of long-term, daily oral administration of grapiprant, a novel drug for treatment ofosteoarthritic pain and inflammation, in healthy dogs. Am J Vet Res. 2015 Oct;76(10):853-9.3. Rahman MJ, et al. Restoration of the type I IFN-IL-1 balance through targeted blockade of PTGER4 inhibits autoimmunity in NOD mice.JCI Insight. 2018 Feb 8;3(3). pii: 97843.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Te