Fostamatinib-disodium-hexahydrate-R788-disodium-hexahydrate-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEFostamatinib disodium hexahydrateCat. No.: HY-13038BCAS No.: 914295-16-2Synonyms: R788 (disodium hexahydrate)分式: CHFNNaOP.HO分量: 732.51作靶点: Syk作通路: Protein Tyrosine Kinase/RTK储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 mo

2、nths-20C 1 month溶解性数据体外实验 DMSO : 31.81 mg/mL (43.43 mM; Need ultrasonic)H2O : 6.6 mg/mL (9.01 mM; Need ultrasonic and warming)Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 1.3652 mL 6.8258 mL 13.6517 mL5 mM 0.2730 mL 1.3652 mL 2.7303 mL10 mM 0.1365 mL 0.6826 mL 1.3652 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配

3、制储备液，并请注意储备液的保存式和期限。BIOLOGICAL ACTIVITY物活性 Fostamatinib disodium hexahydrate (R788 disodium hexahydrate)是R406的原药，为Syk抑制剂，IC50为41nM。IC50 & Target Syk1/2 Master of Small Molecules 您边的抑制剂师www.MedChemE户使本产品发表的科研献 Nat Med. 2018 Feb;24(2):232-238. Cancer Cell. 2014 Feb 10;25(2):226-42. Sci Transl Med. 201

4、8 Jul 18;10(450). pii: eaaq1093. Blood Cancer J. 2014 Aug 22;4:e240.See more customer validations on HYPERLINK / www.MedChemEREFERENCES1. Braselmann, S., et al. R406, an orally available spleen tyrosine kinase inhibitor blocks fc receptor signaling and reduces immunecomplex-mediated inflammation. J

5、Pharmacol Exp Ther, 2006. 319(3): p. 998-1008.2. Chen, L., et al., SYK-dependent tonic B-cell receptor signaling is a rational treatment target in diffuse large B-cell lymphoma. Blood,2008. 111(4): p. 2230-7.3. Suljagic, M., et al., The Syk inhibitor fostamatinib disodium (R788) inhibits tumor growth in the Emu- TCL1 transgenic mouse model ofCLL by blocking antigen-dependent B-cell receptor signaling. Blood, 2010. 116(23): p. 4894-905.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-37