N33-TEG-COOH-N3-TEG-COOH-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEN33-TEG-COOHCat. No.: HY-108370CAS No.: 201467-81-4Synonyms: N3-TEG-COOH; 14-Azido-3,6,9,12-tetraoxatetradecanoic acid分式: CHNO分量: 277.27作靶点: PROTAC Linker作通路: PROTAC储存式: Pure form -20C 3 years4C 2 yearsIn solvent -80C 6 months-2

2、0C 1 month溶解性数据体外实验 DMSO : 100 mg/mL (360.66 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 3.6066 mL 18.0330 mL 36.0659 mL5 mM 0.7213 mL 3.6066 mL 7.2132 mL10 mM 0.3607 mL 1.8033 mL 3.6066 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验请根据您的实验动物和给药式

3、选择适当的溶解案，配制前请先配制澄清的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作液，建议您现现配，当天使；澄清的储备液可以根据储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (9.02 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (9.02 mM); Clear

4、 solution1/2 Master of Small Molecules 您边的抑制剂师www.MedChemE3. 请依序添加每种溶剂： 10% DMSO 90% corn oilSolubility: 2.5 mg/mL (9.02 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 N33-TEG-COOH种 PROTAC 连接桥，含有四个聚醇 (PEG) 单元。详细信息请看参考献 PMID:26035625 中的 Compound 7。IC50 & Target PROTAC linker 1体外研究 N33-TEG-COOH is a long l

5、inker extracted from Reference PMID: 26035625, Compound 7. A PROTAC is aheterobifunctional compound that contains two ligands connected by a linker unit. One ligand binds an E3ubiquitin ligase protein, while the other ligand binds to the target protein of interest, thereby bringing theligase and the

6、 target in close proximity 1.REFERENCES1. Zengerle M, et al. Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4. ACS Chem Biol. 2015 Aug21;10(8):1770-7.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-