URB-597-KDS-4103-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEURB-597Cat. No.: HY-10864CAS No.: 546141-08-6Synonyms: KDS-4103分式: CHNO分量: 338.4作靶点: FAAH; Autophagy; Mitophagy作通路: Metabolic Enzyme/Protease; Neuronal Signaling; Autophagy储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 mont

2、hs-20C 1 month溶解性数据体外实验 DMSO : 100 mg/mL (295.51 mM)H2O : 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (7.39 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% corn oil1/2 Master of Small Molecules 您边的抑制剂师www.MedChemESolubility: 2.5 mg/mL (7.39 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 URB597服物相容性的FAA

3、H抑制剂，IC50为4.6 nM，对其它的cannabinoid-相关靶点活性。REFERENCES1. Mor M, et al. Cyclohexylcarbamic acid 3- or 4-substituted biphenyl-3-yl esters as fatty acid amide hydrolase inhibitors: synthesis,quantitative structure-activity relationships, and molecular modeling studies. J Med Chem, 2004, 47(21), 4998-5008.2

4、. Tham CS, et al. Inhibition of microglial fatty acid amide hydrolase modulates LPS stimulated release of inflammatory mediators. FEBSLett, 2007, 581(16), 2899-2904.3. Fegley D, et al. Characterization of the fatty acid amide hydrolase inhibitor cyclohexyl carbamic acid 3-carbamoyl-biphenyl-3-yl est

5、er(URB597): effects on anandamide and oleoylethanolamide deactivation. J Pharmacol Exp Ther. 2005 Apr;313(1):352-8.4. Jayamanne A, et al. Actions of the FAAH inhibitor URB597 in neuropathic and inflammatory chronic pain models. Br J Pharmacol, 2006,147(3), 281-288.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 021-5