Blonanserin-AD-5423-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEBlonanserinCat. No.: HY-13575CAS No.: 132810-10-7Synonyms: AD-5423分式: CHFN分量: 367.5作靶点: 5-HT Receptor; Dopamine Receptor作通路: GPCR/G Protein; Neuronal Signaling储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 mont

2、h溶解性数据体外实验 DMSO : 14.29 mg/mL (38.88 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 2.7211 mL 13.6054 mL 27.2109 mL5 mM 0.5442 mL 2.7211 mL 5.4422 mL10 mM 0.2721 mL 1.3605 mL 2.7211 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄清的储备液，再依次添加助溶剂

3、(为保证实验结果的可靠性，体内实验的作液，建议您现现配，当天使；澄清的储备液可以根据储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 1.43 mg/mL (3.89 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 1.43 mg/mL (3.89 mM); Clear solution3. 请依序添加每种溶剂： 10% DM

4、SO 90% corn oil1/2 Master of Small Molecules 您边的抑制剂师www.MedChemESolubility: 1.43 mg/mL (3.89 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 Blonanserin(AD-5423)是D2/5-HT2受体拮抗剂。REFERENCES1. Tenjin, T., et al., Profile of blonanserin for the treatment of schizophrenia. Neuropsychiatr Dis Treat, 2013. 9: p.

5、587-94.2. Oka, M., et al., Pharmacological profile of AD-5423, a novel antipsychotic with both potent dopamine-D2 and serotonin-S2 antagonistproperties. J Pharmacol Exp Ther, 1993. 264(1): p. 158-65.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 021-5895