EHT-1864 - Ras 抑制剂 - 生命科学试剂 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEEHT 1864Cat. No.: HY-16659CAS No.: 754240-09-0分式: CHClFNOS分量: 581.48作靶点: Ras作通路: GPCR/G Protein储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 H2O : 100 mg/mL (171.97 mM)DMSO : 32 mg/mL (55.03 mM)

2、* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 1.7197 mL 8.5987 mL 17.1975 mL5 mM 0.3439 mL 1.7197 mL 3.4395 mL10 mM 0.1720 mL 0.8599 mL 1.7197 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。BIOLOGICAL ACTIVITY物活性 EHT 1864是Rac1信号转导抑制剂，能调节_gamma_-分泌酶介导的APP。户

3、使本产品发表的科研献1/2 Master of Small Molecules 您边的抑制剂师www.MedChemE J Pathol. 2017 Oct;243(2):208-219. Front Immunol. 2018 Aug 31;9:1987.See more customer validations on HYPERLINK / www.MedChemEREFERENCES1. Desire L, et al. RAC1 inhibition targets amyloid precursor protein processing by gamma-secretase and

4、decreases Abeta production invitro and in vivo. J Biol Chem. 2005 Nov 11;280(45):37516-25.2. Shutes A, et al. Specificity and mechanism of action of EHT 1864, a novel small molecule inhibitor of Rac family small GTPases. J BiolChem. 2007 Dec 7;282(49):35666-78.3. Onesto C, et al. Characterization of EHT 1864, a novel small molecule inhibitor of Rac family small GTPases. Methods Enzymol.2008;439:111-29.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;