N-p-amylcinnamoyl-Anthranilic-Acid-ACA-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEN-(p-amylcinnamoyl) Anthranilic AcidCat. No.: HY-118628CAS No.: 110683-10-8Synonyms: ACA分式: CHNO分量: 337.41作靶点: Phospholipase; TRP Channel作通路: Metabolic Enzyme/Protease; Membrane Transporter/IonChannel; Neuronal Signaling储存式: Pow

2、der -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 125 mg/mL (370.47 mM)H2O : 40% PEG300 5% Tween-80 45% salineSolubility: 2.08 mg/mL (6.16 mM); Clear solution1/2 Master of Small Molecules 您边的抑制剂师www.MedChemE2. 请依序添加每种溶剂： 10% DMSO 90% corn oilSolubility: 2.08 mg/mL (6.16

3、mM); Clear solutionBIOLOGICAL ACTIVITY物活性 N-(p-amylcinnamoyl) Anthranilic Acid (ACA)种谱磷脂酶A2 (PLA2) 的抑制剂，TRP 通道的阻滞剂。N-(p-amylcinnamoyl) Anthranilic Acid (ACA) 也 种有效的钙离激活氯通道 (calcium-activated chloridechannels) 的可逆抑制剂，具有治疗律失常的潜能。IC50 & Target PLA2 1 2.TRP channel 1 2.Calcium-activated chloride channel

4、s 3.体外研究 N-(p-amylcinnamoyl) Anthranilic Acid (ACA; 20 M) completely blocks ADPR-induced whole-cell currentsand H2O2-induced Ca2+ signals (IC50=1.7 M) in HEK293cells transfected with human TRPM2 1.N-(p-amylcinnamoyl) Anthranilic Acid (ACA; 20 M) also blocks currents through human TRPM8 and TRPC6expr

5、essed in HEK293 cells 1.N-(p-amylcinnamoyl) Anthranilic Acid (ACA) modulates the activity of different TRP channels independent ofPLA22 inhibition 1.REFERENCES1. Kraft R, et al. Inhibition of TRPM2 cation channels by N-(p-amylcinnamoyl)anthranilic acid. Br J Pharmacol. 2006 Jun;148(3):264-73.2. Hart

6、eneck C, et al. N-(p-amylcinnamoyl)anthranilic acid (ACA): a phospholipase A(2) inhibitor and TRP channel blocker. CardiovascDrug Rev. 2007 Spring;25(1):61-75.3. Gwanyanya A, et al. Inhibition of the calcium-activated chloride current in cardiac ventricular myocytes by N-(p-amylcinnamoyl)anthranilic acid (ACA). Biochem Biophys Res Commun. 2010 Nov 19;402(3):531-6.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: