L-152804 - NPY Y5 Receptor Antagonist - 生命科学试剂 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEL 152804Cat. No.: HY-107734CAS No.: 6508-43-6分式: CHO分量: 366.45作靶点: Neuropeptide Y Receptor作通路: GPCR/G Protein; Neuronal Signaling储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 125 mg/mL (3

2、41.11 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 2.7289 mL 13.6444 mL 27.2889 mL5 mM 0.5458 mL 2.7289 mL 5.4578 mL10 mM 0.2729 mL 1.3644 mL 2.7289 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄清的储备液，再依次添加助溶剂(为保证实验结果

3、的可靠性，体内实验的作液，建议您现现配，当天使；澄清的储备液可以根据储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.08 mg/mL (5.68 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.08 mg/mL (5.68 mM); Clear solution3. 请依序添加每种溶剂： 10% DMSO 90% c

4、orn oil1/2 Master of Small Molecules 您边的抑制剂师www.MedChemESolubility: 2.08 mg/mL (5.68 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 L 152804服有效的、选择性的神经肽 Y Y5受体 (NPY5-R) 的拮抗剂，其对hY5 的Ki 值为 26 nM。L 152804通过调节物摄和能量消耗，使饮引起的肥胖体重 减轻。IC50 & Target Ki: 26 nM (NPY5-R) 1.体外研究 L 152804 displays 300-fold selectivity

5、over hY1, hY2, and hY4 receptors 1.REFERENCES1. Kanatani A, et al. L-152,804: orally active and selective neuropeptide Y Y5 receptor antagonist. Biochem Biophys Res Commun. 2000May 27;272(1):169-73.2. Mashiko S, et al. A pair-feeding study reveals that a Y5 antagonist causes weight loss in diet-induced obese mice by modulating foodintake and energy expenditure. Mol Pharmacol. 2007 Feb;71(2):602-8. Epub 2006 Nov 14.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-379