4-Hydroxybenzyl-alcohol - Apoptosis Activator - 生命科学试剂 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemE4-Hydroxybenzyl alcoholCat. No.: HY-Y0892CAS No.: 623-05-2分式: CHO分量: 124.14作靶点: Apoptosis作通路: Apoptosis储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 100 mg/mL (805.54 mM; Need ultrasonic)

2、Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 8.0554 mL 40.2771 mL 80.5542 mL5 mM 1.6111 mL 8.0554 mL 16.1108 mL10 mM 0.8055 mL 4.0277 mL 8.0554 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验 请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄清的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作液，建议您现现配，当天使；澄清的储备液可以根据储存条件，适当保存；以下溶

3、剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (20.14 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (20.14 mM); Clear solution3. 请依序添加每种溶剂： 10% DMSO 90% corn oilSolubility: 2.5 mg/mL (20.14 mM); Clear

4、solution1/2 Master of Small Molecules 您边的抑制剂师www.MedChemEBIOLOGICAL ACTIVITY物活性 4-Hydroxybenzyl alcohol泛分布于各种植物中的酚类化合物。 具有抗炎，抗氧化，抗伤害感受活性。 神经保护作。 抑制肿瘤管成和长 1 2 3 4。体外研究 4-Hydroxybenzyl alcohol inhibits proliferation of eEND2 cells and suppresses the migration of eEND2 cells,accompanied by inhibition o

5、f actin filament reorganization 2.4-Hydroxybenzyl alcohol induces apoptotic death of tumor cells 3.体内研究 4-Hydroxybenzyl alcohol possesses antiangiogenic, anti-inflammatory and anti-nociceptive activity possiblyvia its down-regulating activity on NO production 1.4-Hydroxybenzyl alcohol (200 mg/kg) ef

6、ficiently inhibits growth and angiogenesis of developing tumors 3.4-Hydroxybenzyl alcohol ameliorates ischemic injury induced by transient focal cerebral ischemia in rats, andthis neuroprotective effect may be partly related to attenuate apoptosis pathway 4.REFERENCES1. Lim EJ, et al. Anti-angiogeni

7、c, anti-inflammatory and anti-nociceptive activity of 4-hydroxybenzyl alcohol. J Pharm Pharmacol. 2007Sep;59(9):1235-40.2. Laschke MW, et al. In vitro and in vivo evaluation of the anti-angiogenic actions of 4-hydroxybenzyl alcohol. Br J Pharmacol. 2011Jun;163(4):835-44.3. Laschke MW, et al. 4-hydro

8、xybenzyl alcohol: a novel inhibitor of tumor angiogenesis and growth. Life Sci. 2013 Jul 19;93(1):44-50.4. Yu SS, et al. Neuroprotective effect of 4-hydroxybenzyl alcohol against transient focal cerebral ischemia via anti-apoptosis in rats. BrainRes. 2010 Jan 13;1308:167-75.McePdfHeightCaution: Product has not been fully validated for medical applications.