SB-242084 - 5-HT Receptor Antagonist - 生命科学试剂 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemESB 242084Cat. No.: HY-13409CAS No.: 181632-25-7分式: CHClNO分量: 394.85作靶点: 5-HT Receptor作通路: GPCR/G Protein; Neuronal Signaling储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 44 mg/mL (111.43

2、mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 2.5326 mL 12.6630 mL 25.3261 mL5 mM 0.5065 mL 2.5326 mL 5.0652 mL10 mM 0.2533 mL 1.2663 mL 2.5326 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。BIOLOGICAL ACTIVITY物活性 SB 2420845-HT2C选择性抑制剂，pKi值9.0，对5-HT2A和5

3、-HT2B作弱100倍以上。REFERENCES1. Kennett GA, et al. SB 242084, a selective and brain penetrant 5-HT2C receptor antagonist. Neuropharmacology. 1997 Apr-May;36(4-5):609-20.1/2 Master of Small Molecules 您边的抑制剂师www.MedChemE2. Bromidge SM, et al. 6-Chloro-5-methyl-1-2-(2-methyl-3-pyridyl)oxy-5-pyridylcarbamoyl

4、- indoline (SB-242084): the first selective andbrain penetrant 5-HT2C receptor antagonist. J Med Chem. 1997 Oct 24;40(22):3494-6.3. Dalton GL, et al. Serotonin 1B and 2C receptor interactions in the modulation of feeding behaviour in the mouse. Psychopharmacology(Berl). 2006 Mar;185(1):45-57.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;Fax: