Imidazole-ketone-erastin-IKE-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEImidazole ketone erastinCat. No.: HY-114481CAS No.: 1801530-11-9Synonyms: IKE分式: CHClNO分量: 655.14作靶点: Ferroptosis作通路: Apoptosis储存式: 4C, sealed storage, away from moisture and light* In solvent : -80C, 6 months; -20C, 1 month (se

2、aledstorage, away from moisture and light)溶解性数据体外实验 DMSO : 125 mg/mL (190.80 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 1.5264 mL 7.6320 mL 15.2639 mL5 mM 0.3053 mL 1.5264 mL 3.0528 mL10 mM 0.1526 mL 0.7632 mL 1.5264 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并

3、请注意储备液的保存式和期限。体内实验 请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄清的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作液，建议您现现配，当天使；澄清的储备液可以根据储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.08 mg/mL (3.17 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% corn oilSolubility: 2.08 mg

4、/mL (3.17 mM); Clear solution1/2 Master of Small Molecules 您边的抑制剂师www.MedChemEBIOLOGICAL ACTIVITY物活性 Imidazole ketone erastin (IKE)种有效的，选择性的，代谢稳定的胱氨酸-氨酸逆转运蛋，system Xc-抑制剂和 ferroptosis 活化剂。IC50 & Target System Xc-, ferroptosis 1REFERENCES1. Zhang Y, et al. Imidazole Ketone Erastin Induces Ferroptosis and Slows Tumor Growth in a Mouse Lymphoma Model. Cell Chem Biol.2019 Jan 31. pii: S2451-9456(19)30030-3.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;