Dabigatran-etexilate-BIBR-1048-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEDabigatran etexilateCat. No.: HY-10274CAS No.: 211915-06-9Synonyms: BIBR 1048分式: CHNO分量: 627.73作靶点: Thrombin作通路: Metabolic Enzyme/Protease储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 100

2、 mg/mL (159.30 mM)H2O : 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (3.98 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% corn oil1/2 Master of Small Molecules 您边的抑制剂师www.MedChemESolubility: 2.5 mg/mL (3.98 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 Dabigatran etexilate(BIBR-1048)服活性的dabigat

3、ran原药， 可逆的直接凝酶抑制剂（DTI），Ki为4.5 nM。户使本产品发表的科研献 Biochem Pharmacol. 2016 Nov 1;119:76-84. J Chromatogr Sci. 2016 Jul 29;54(9):1648-1651.See more customer validations on HYPERLINK / www.MedChemEREFERENCES1. Wienen W, Stassen JM, Priepke H, In-vitro profile and ex-vivo anticoagulant activity of the direct

4、 thrombin inhibitor dabigatran and itsorally activeprodrug, dabigatran etexilate. Thromb Haemost. 2007 Jul;98(1):155-62.2. Kansal AR, Sorensen SV, Gani R, Cost-effectiveness of dabigatran etexilate for the prevention of stroke and systemic embolism in UKpatients withatrial fibrillation. Heart. 2012 Apr;98(7):573-8.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;Fax: