2-Methylsuccinic-acid - Endogenous Metabolite - 生命科学试剂 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemE2-Methylsuccinic acidCat. No.: HY-W010381CAS No.: 498-21-5分式: CHO分量: 132.12作靶点: Endogenous Metabolite作通路: Metabolic Enzyme/Protease储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 100 mg/mL

2、(756.89 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 7.5689 mL 37.8444 mL 75.6888 mL5 mM 1.5138 mL 7.5689 mL 15.1378 mL10 mM 0.7569 mL 3.7844 mL 7.5689 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄清的储备液，再依次添加助溶剂(为保证实

3、验结果的可靠性，体内实验的作液，建议您现现配，当天使；澄清的储备液可以根据储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (18.92 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (18.92 mM); Clear solution3. 请依序添加每种溶剂： 10% DMSO 90

4、% corn oil1/2 Master of Small Molecules 您边的抑制剂师www.MedChemESolubility: 2.5 mg/mL (18.92 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 2-Methylsuccinic acid体液中的种正常代谢物， 丙酸脑病的主 化指标。IC50 & Target Human Endogenous Metabolite体外研究 2-Methylsuccinic acid is a normal metabolite in human fluids and the main bioche

5、mical measurable featuresin ethylmalonic encephalopathy 1. The underlying biochemical defect involves isoleucine catabolism 2.REFERENCES1. Grosso S, et al. Ethylmalonic encephalopathy: further clinical and neuroradiological characterization. J Neurol. 2002 Oct;249(10):1446-50.2. Nowaczyk MJ, et al. Ethylmalonic and methylsuccinic aciduria in ethylmalonic encephalopathy arise from abnormal isoleucinemetabolism. Metabolism. 1998 Jul;47(7):836-9.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-37