DHBP-dibromide-Diheptylviologen-dibromide-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEDHBP dibromideCat. No.: HY-101237CAS No.: 6159-05-3Synonyms: Diheptylviologen dibromide分式: CHBrN分量: 514.38作靶点: Calcium Channel作通路: Membrane Transporter/Ion Channel; Neuronal Signaling储存式: Powder -20C 3 years4C 2 yearsIn solvent

2、-80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 30 mg/mL (58.32 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 1.9441 mL 9.7204 mL 19.4409 mL5 mM 0.3888 mL 1.9441 mL 3.8882 mL10 mM 0.1944 mL 0.9720 mL 1.9441 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。BIOLO

3、GICAL ACTIVITY物活性 DHBP dibromide钙离释放的抑制剂和肌松弛剂。体外研究DHBP inhibits the calcium release induced by 2 mM caffeine and 2 g/mL polylysine with an IC50 value of 5g/mL and 4 g/mL, respectively. DHBP inhibits 3H-ryanodine binding in a dose-dependent manner with anIC50 of 2.5 g/mL and 90-100% inhibition at 20-

4、30 g/mL. Calcium uptake by SR is inhibited in the presence1/2 Master of Small Molecules 您边的抑制剂师www.MedChemEof caffeine and this inhibition is antagonized by concomitant addition of DHBP. Muscle twitches elicited bydirect electrical muscle stimulation and contractions induced by either 10 mM caffeine

5、 or 1 fLM ryanodine areblocked by pretreatment with DHBP. DHBP blocks the calcium release from SR by direct interaction with thecalcium release channel, also known as the ryanodine receptor 1.REFERENCES1. Kang JJ, et al. Effects of bipyridylium compounds on calcium release from triadic vesicles isolated from rabbit skeletal muscle. Br JPharmacol. 1994 Aug;112(4):1216-22.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;