Ceftobiprole-Ro-63-9141-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemECeftobiproleCat. No.: HY-112579CAS No.: 209467-52-7Synonyms: Ro 63-9141; BAL 9141分式: CHNOS分量: 534.57作靶点: Bacterial作通路: Anti-infection储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 5 mg/mL

2、(9.35 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 1.8707 mL 9.3533 mL 18.7066 mL5 mM 0.3741 mL 1.8707 mL 3.7413 mL10 mM - - -请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄清的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作液，建议您现现配，当天使；澄清的储备液可以根据储存条件，适当保存；以下溶剂

3、前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 0.5 mg/mL (0.94 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 0.5 mg/mL (0.94 mM); Clear solution3. 请依序添加每种溶剂： 10% DMSO 90% corn oil1/2 Master of Small Molecules 您边的抑制剂师www.Me

4、dChemESolubility: 0.5 mg/mL (0.94 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 Ceftobiprole种谱头孢 素，可有效作于甲氧西林耐受的 葡萄球菌(MRSA)，MIC90 值为 2mcg/mL。IC50 & Target MIC90: 2 mcg/mL (MRSA) 1体外研究 Ceftobiprole has demonstrates activity against important gram-positive bacteria, including penicillin-resistantS. pneumon

5、ia (PRSP), Methicillin-resistant S. aureus (MRSA), and E. faecalis with MIC90 values of 0.25, 2,and 2 mcg/mL, respectively. Ceftobiprole has also demonstrated potent in vitro activity against severalclinical isolates of community-associated Methicillin-resistant S. aureus (CA-MRSA), vancomycin-inter

6、mediate S. aureus (VISA), and Vancomycin-resistant S. aureus (VRSA), with a minimum inhibitoryconcentration (MIC) of 2 mcg/mL 1. Ceftobiprole is highly active against S. aureus, withMICs ranging from0.12 to 4 mg/L (only one resistant strain,MIC of 4 mg/L). Furthermore, Ceftobiprole is twice more act

7、ive onMethicillin-susceptible S. aureus (MSSA) strains with MIC50 and MIC90 of 0.5 mg/L than on MRSA strainswith MIC50 and MIC90 of 1 mg/L. Moreover, Panton-Valentine leukocidin (PVL)+MRSA are slightly moresusceptible to Ceftobiprole (MIC50 of 0.5 mg/L and MIC90 of 1 mg/L) than PVL-MRSA (MIC50 and M

8、IC90 of1 mg/L) 2.REFERENCES1. Kisgen J, et al. Ceftobiprole, a Broad-Spectrum Cephalosporin With Activity against Methicillin-Resistant Staphylococcus aureus(MRSA). P T. 2008 Nov;33(11):631-41.2. Hodille E, et al. In vitro activity of ceftobiprole on 440 Staphylococcus aureus strains isolated from bronchopulmonary infections. MedMal Infect. 2017 Mar;47(2):152-157.McePdfHeightCaution: Product has not been fully validated for medical applicati