BAY-1895344-hydrochloride-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEBAY-1895344 hydrochlorideCat. No.: HY-101566A分式: CHClNO分量: 411.89作靶点: ATM/ATR作通路: Cell Cycle/DNA Damage; PI3K/Akt/mTOR储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 54 mg/mL (131.10 mM; Ne

2、ed ultrasonic and warming)H2O : 50 mg/mL (121.39 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 2.4278 mL 12.1392 mL 24.2783 mL5 mM 0.4856 mL 2.4278 mL 4.8557 mL10 mM 0.2428 mL 1.2139 mL 2.4278 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。BIOLOGICAL ACTIVITY物活性 BAY-1895344 h

3、ydrochloride种有效、可服、选择性的 ATR 抑制剂，IC50 值为 7 nM。具有抗肿瘤活性1。IC50 & Target ATR7 nM (IC50)体外研究BAY-1895344 potently inhibits the proliferation of a broad spectrum of human tumor cell lines with a medianIC50 of 78 nM 1.1/2 Master of Small Molecules 您边的抑制剂师www.MedChemEBAY-1895344 potently suppresses hydroxyure

4、a-induced H2AX phosphorylation (IC50, 36 nM) 1.体内研究 BAY-1895344 shows potent anti-tumor efficacy in monotherapy in a variety of xenograft models of ovarianand colorectal cancer, and causes complete tumor remission in mantle cell lymphoma models 2.REFERENCES1. Ulrich T. Luecking, et al. Abstract 983:

5、 Identification of potent, highly selective and orally available ATR inhibitor BAY 1895344 withfavorable PK properties and promising efficacy in monotherapy and combination in preclinical tumor models. Cancer Research. July 2017Volume 77, Issue 13 Supplement.2. Antje Margret Wengner, et al. Abstract

6、 836: ATR inhibitor BAY 1895344 shows potent anti-tumor efficacy in monotherapy and strongcombination potential with the targeted alpha therapy Radium-223 dichloride in preclinical tumor models. Cancer Research. July 2017Volume 77, Issue 13 SupplementMcePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-