Cardamonin-Cardamomin-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemECardamoninCat. No.: HY-N0279CAS No.: 18956-16-6Synonyms: Cardamomin; Alpinetin chalcone分式: CHO分量: 270.28作靶点: NOD-like Receptor (NLR); Aryl Hydrocarbon Receptor作通路: Immunology/Inflammation储存式: Please store the product under the r

2、ecommended conditions inthe COA.溶解性数据体外实验 DMSO : 130 mg/mL (480.98 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 3.6999 mL 18.4993 mL 36.9987 mL5 mM 0.7400 mL 3.6999 mL 7.3997 mL10 mM 0.3700 mL 1.8499 mL 3.6999 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验 请根据您的实验动物和给药式

3、选择适当的溶解案，配制前请先配制澄的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作液，建议您现现配，当天使；澄的储备液可以根据储存条件，适当保存；以下溶剂前的百分指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.17 mg/mL (8.03 mM); Clear solutionBIOLOGICAL ACTIVITY物活性Cardamonin (Cardamomin)，种从 Alpinia katsumadai Hayata 中分离的天然酮类化合物，Ca

4、rdamonin作芳烃受体 (AhR) 激活剂。 Cardamonin 通过 AhR/Nrf2/NQO1 途径抑制 NLRP3 炎性体激活来减轻炎症性肠1/2 Master of Small Molecules 您边的抑制剂师www.MedChemE病 1。IC50 & Target NLRP3REFERENCES1. Wang K, et al. Cardamonin, a natural flavone, alleviates inflammatory bowel disease by the inhibition of NLRP3 inflammasomeactivation via an AhR/Nrf2/NQO1 pathway. Biochem Pharmacol. 2018 Sep;155:494-509.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;Fa