Acetyl-CoA-Carboxylase-Inhibitors-Modulators-生命科学试剂-MedChemExpress

1、 HYPERLINK https:/www.MedChemE/Targets/Acetyl-CoA Carboxylase.html Acetyl-CoA HYPERLINK https:/www.MedChemE/Targets/Acetyl-CoA Carboxylase.html HYPERLINK https:/www.MedChemE/Targets/Acetyl-CoA Carboxylase.html CarboxylaseACC, Acetyl Coenzyme A CarboxylaseAcetyl-CoA carboxylase catalyzes the ATP-depe

2、ndent carboxylation of acetyl-CoA, a rate-limiting step in fatty acid biosynthesis.Acetyl-CoA carboxylase has crucial roles in fatty acid metabolism and is an attractive target for drug discovery against diabetes,cancer, and other diseases.In animals, there are two major isoforms of ACCs, ACC1, and

3、ACC2, which are encoded by different genes and display distinct tissueand cellular distribution. The first committed step of fatty acid synthesis (FASyn) is mediated by ACC, which in mammals is encodedby two related enzymes ACC1 and ACC2, which catalyze the ATP-dependent carboxylation of acetyl-CoA

4、to form malonyl-CoA.ACC1 encodes a cytoplasmic isoform that is thought to be the predominant isoform controlling FASyn, whereas ACC2 is tethered tothe mitochondrial outer membrane, where localized malonyl-CoA production blocks carnitine palmitoyltransferase-1 (CPT-1)function to prevent fatty acids f

5、rom entering the mitochondria to undergo fatty acid oxidation (FAOxn).www.MedChemE 1 HYPERLINK https:/www.MedChemE/Targets/Acetyl-CoA Carboxylase.html Acetyl-CoA HYPERLINK https:/www.MedChemE/Targets/Acetyl-CoA Carboxylase.html HYPERLINK https:/www.MedChemE/Targets/Acetyl-CoA Carboxylase.html Carbox

6、ylase HYPERLINK https:/www.MedChemE/Targets/Acetyl-CoA Carboxylase.html HYPERLINK https:/www.MedChemE/Targets/Acetyl-CoA Carboxylase.html Inhibitors HYPERLINK https:/www.MedChemE/a-908292.html A-908292 HYPERLINK https:/www.MedChemE/a-908292.html HYPERLINK https:/www.MedChemE/cms-121.html CMS-121Cat.

7、 No.: HY-147004 Cat. No.: HY-135981A-908292 is a potent and selective acetyl-CoAcarboxylase 2 (ACC2) inhibitor, with an IC of38 nM. A-908292 can be used for the research offatty acid metabolism.CMS-121 is a quinolone derivative and an orallyactive acetyl-CoA carboxylase 1 (ACC1) inhibitor.CMS-121 pr

8、otects HT22 cells against ischemia andoxidative damage with EC values of 7 nM and200 nM, respectively.Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mgPurity: 99.63%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 5 mg HYPERLINK https:/www.MedChemE/cp-610431.html CP-610431 HYP

9、ERLINK https:/www.MedChemE/cp-610431.html HYPERLINK https:/www.MedChemE/CP-640186.html CP-640186Cat. No.: HY-16946 Cat. No.: HY-15259CP-610431 is a reversible, ATP-uncompetitive,isozyme-nonselective acetyl-CoA carboxylase (ACC)inhibitor. CP-610431 inhibits ACC1 and ACC2 withIC s of 50 nM. CP-610431

10、can be used for theresearch of metabolic syndrome.CP-640186 is a potent and cell-permeable Acetyl-CoAcarboxylase (ACC) inhibitor with IC s of 53 nMand 61 nM for rat liver ACC1 and rat skeletalmuscle ACC2 respectively.Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mgPurity: 98.92%Clin

11、ical Data: No Development ReportedSize: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/CP-640186-hydrochloride.html CP-640186 HYPERLINK https:/www.MedChemE/CP-640186-hydrochloride.html HYPERLINK https:/www.MedChemE/CP-640186-hydrochloride.html hydrochlorideCat. No.: HY-15259A HYPERLINK https:/www.MedChemE

12、/ND-630.html Firsocostat(ND-630; GS-0976; NDI-010976) Cat. No.: HY-16901CP-640186 hydrochloride is a potent andcell-permeable Acetyl-CoA carboxylase (ACC)inhibitor with IC s of 53 nM and 61 nM for ratliver ACC1 and rat skeletal muscle ACC2respectively.Firsocostat (ND-630; GS-0976; NDI-010976) is ana

13、cetyl-CoA carboxylase (ACC) inhibitor; inhibitshuman ACC1 and ACC2 with IC values of 2.1 and6.1 nM, respectively.Purity: 99.81%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 5 mg, 10 mg, 50 mg, 100 mgPurity: 99.48%Clinical Data: Phase 2Size: 10 mM 1 mL, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg HYP

14、ERLINK https:/www.MedChemE/fluazifop-p-butyl.html Fluazifop-P-butyl HYPERLINK https:/www.MedChemE/fluazifop-p-butyl.html HYPERLINK https:/www.MedChemE/haloxyfop.html HaloxyfopCat. No.: HY-B2007 Cat. No.: HY-B1856Fluazifop-P-butyl, a graminicide fromarylophenoxypropionate group, is a acetyl-CoAcarbox

15、ylase (ACCase) inhibitor.Haloxyfop is an aryloxyphenoxypropionic acidherbicide and is widely used in grass weeds inbroad-leaf crops. Haloxyfop inhibits the acetylcoenzyme A carboxylase (EC ) from cornseedling chloroplasts with an IC of 0.5 M, buthas no effect on this enzyme in pea.Purity: 98.98%Clin

16、ical Data: No Development ReportedSize: 10 mM 1 mL, 50 mgPurity: 98%Clinical Data: No Development ReportedSize: 5 mg, 10 mg, 25 mg HYPERLINK https:/www.MedChemE/MK-4074.html MK-4074 HYPERLINK https:/www.MedChemE/MK-4074.html HYPERLINK https:/www.MedChemE/ND-646.html ND-646Cat. No.: HY-107709 Cat. No

17、.: HY-101842MK-4074 is a liver-specific inhibitor of acetyl-CoAcarboxylaseACC1 and ACC2 with IC values ofapproximately 3 nM.ND-646 is an orally bioavailable and stericinhibitor of acetyl-CoA carboxylase (ACC) withIC s of 3.5 nM and 4.1 nM for recombinant hACC1and hACC2, respectively.Purity: 99.71%Cl

18、inical Data: No Development ReportedSize: 10 mM 1 mL, 5 mg, 10 mg, 25 mg, 50 mg, 100 mgPurity: 99.53%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg2 Tel: 609-228-6898 Fax: 609-228-5909 Email: salesMedChemE HYPERLINK https:/www.MedChemE/Olumacostat_glasareti

19、l.html Olumacostat HYPERLINK https:/www.MedChemE/Olumacostat_glasaretil.html HYPERLINK https:/www.MedChemE/Olumacostat_glasaretil.html glasaretil HYPERLINK https:/www.MedChemE/Olumacostat_glasaretil.html HYPERLINK https:/www.MedChemE/PF-05175157.html PF-05175157Cat. No.: HY-17641 Cat. No.: HY-12942O

20、lumacostat glasaretil is a small moleculeinhibitor of acetyl coenzyme A carboxylase (ACC).PF-05175157 is broad spectrum acetyl-CoA carboxylase(ACC) inhibitor with IC s of 27.0, 33.0, 23.5and 50.4 nM for ACC1 (human), ACC2 (human), ACC1(rat), ACC2 (rat), respectively.Purity: 98.90%Clinical Data: Phas

21、e 3Size: 10 mM 1 mL, 1 mg, 5 mg, 10 mg, 50 mg, 100 mg, 200 mgPurity: 98.77%Clinical Data: Phase 2Size: 10 mM 1 mL, 5 mg, 10 mg, 25 mg, 50 mg HYPERLINK https:/www.MedChemE/propaquizafop.html Propaquizafop HYPERLINK https:/www.MedChemE/propaquizafop.html HYPERLINK https:/www.MedChemE/s-2e.html S-2ECat. No.: HY-117262 Cat. No.: HY-139134Propaquizafop is a phenox