1-5-Isoquinolinediol-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemE1,5-IsoquinolinediolCat. No.: HY-W015422CAS No.: 5154-02-9分式: CHNO分量: 161.16作靶点: PARP作通路: Cell Cycle/DNA Damage; Epigenetics储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 37.04 mg/mL (229.

2、83 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 6.2050 mL 31.0251 mL 62.0501 mL5 mM 1.2410 mL 6.2050 mL 12.4100 mL10 mM 0.6205 mL 3.1025 mL 6.2050 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。BIOLOGICAL ACTIVITY物活性 1,5-Isoquinolinediol种 有效的 PARP 抑制剂，IC50 值为 0.18-0.37 M。1,5

3、-Isoquinolinediol 减轻糖尿病诱导的视膜 NADPH 氧化酶诱导的氧化应激。IC50 & Target PARP0.18-0.37 M (IC50)体外研究1,5-isoquinolinediol leads to an increase up to 8-fold in the absolute frequency of gene targeting in the1/2 Master of Small Molecules 您边的抑制剂师www.MedChemEcorrection of the mutation at the stable integrated HSV tk g

4、ene 1.1,5-Isoquinolinediol is a potent PARP antagonist and decreases cleaved PARP in diabetic retina.1,5-Isoquinolinediol (500 M H2O2; 24 hours) attenuates H2O2-induced upregulation of cleaved PARP-1expression in retinal Muller cells. 1,5-Isoquinolinediol attenuates diabetes-induced upregulation of

5、retinalnitrated protein expression. 1,5-Isoquinolinediol attenuates diabetes-induced activation of NADPH oxidase inthe retina 2.REFERENCES1. Crockett SL, et al. Role of dopamine and selective dopamine receptor agonists on mouse ductus arteriosus tone and responsiveness.Pediatr Res. 2019 Dec 9.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 021