体会分栏夹杂横贯带脚注型

利多卡因治疗支气管哮喘的初步临床与动物实验研戴山林【】目的探讨……。方法1．哮喘患者……。2．应用卵清蛋白……。结果1．吸（¯±s……。【】雾化吸入；利多卡因……白细胞介素-2受材料与方一、一、材2%盐酸利多卡因DL-赖氨酸单盐酸盐……VM1通气测定仪（VentilometerVM1，ClementClarkeInternationalUK；Sidestream雾化器（Medic-AidUK）……。二、二、方2.1临床研2.1.1入选对2.1.2方2.2动物实验研2.2.1大鼠……分子2.2.1.1正常对照组（A组：……激发。停止激发……2.2.1.2阳性对照组（B组：……大鼠模型[4]2.2.1.3预防治疗组（C组：……取材：……2.2.2取大鼠……，室温……常规石蜡包埋、切片，……卵白素-生物素-过氧化物酶复合体法（ABC）……阳性对照和对照2.2.3作者单位：210029，医学第一附属医院（、、戴山林；南京医学病理学教研室（、）①光镜检查……Underwood等[5]0.1～0.3mm范围的三、三、数据处理与统计学分3.1临床研3.2动物实验研……x结一、一、临1.1FEV1（¯±s）……均＜0.012.1大鼠肺……变化（21～4阳性对照组（B组）……哮喘发作。（P＞0.5一、一、单次吸入……PEF的影响体外细胞培养研究……产生[9]，……Robinson等[10]证实……形成[11]。参考文，利多卡因治疗哮喘的临床新应用国外医学呼吸系统分册2000；20：9-DeccoML,NeenoTA,HuntLW,etal.Nebulizedlidocaineinthetreatmentofsevereasthmainchildren:apilotstudy.AnnAllergyAsthmaImmunol.1999;82:29-32GroebenH,SilvanusMT,BesteM,etal.Bothintravenousandinhaledlidocaineattenuatereflexbronchoconstrictionbutatdifferentplasmaconcentrations.AmJRespirCritCareMed.1999;159（2):530-UnderwoodS,FosterM,RaeburnS,etal.Time-courseofantigen-inducedairwayinflammationintheguinea-piganditsrelationshiptoairwayhyperresponsiveness.EurRespirJ.1995;8:2104-21136．Hunt LW,Swedlund glucocorticoid-dependentasthma.MayoClinProc.1996;71:361-368McAlpineMB,ThomsonNC.Lidocaine-inducedbroncho-constrictioninasthmapatients.Chest.HarrisonTW,TattersfieldAE.EffectofsingledosesofinhaledlignocaineonFEV1andbronchialreactivityinasthma.RespirMed.1998;92:1359-63OkadaS,HaganJB,KatoM,etal.Lidocaineandits oguesinhibitIL-5-mediatedsurvivalandactivationofhumaneosinophils.JImmunol.1998;160:4010-4017RobinsonDS,HamidQ,YingS.PredominantTh2-likebronchoalveolarT-lymphocytepopulationinatopicasthma.NEnglJMed.1992;326:298-304WillianWB,RobertLC,CoffmanEW.Mechanismsofpersistentairwayinflammationinasthma:AroleforTcellsandTcellproducts.AmJRespirCritCareMed.1995;152:388-393PatersonDJ,JefferiesWA,BroansonM,etal.ofactivatedRatTLymphocytesincludingamoleculeof50,000Mr,detectedonlyonCD4positiveTblasts.MolImmunol.1987;24:1281-1290NebulizedLidocaineintheTreatmentofAsthmaticsandRatModelofAsthma:apilotGUJingyu*,YINKaisheng,SUNPeili,etal.*DepartmentofRespiratoryDisease,theHospitalAffiliatedtoNanjingMedicalUniversity,Nanjing210029,China【】ObjectivesToprobeinto…….Methods①Arandomized,double-blind……nebulization.②Therat……observ