CH-0793076-TFA-TP3076-TFA-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•Agonists•ScreeningLibrarieswww.MedChemECH-0793076TFACat.No.:HY-107096BSynonyms:TP3076TFA分⼦式:C₂₈H₂₇F₃N₄O₆分⼦量:572.53作⽤靶点:Topoisomerase作⽤通路:CellCycle/DNADamage储存⽅式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性数据体外实验DMSO:66.67mg/mL(116.45mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制备储备液1mM1.7466mL8.7332mL17.4663mL5mM0.3493mL1.7466mL3.4933mL10mM0.1747mL0.8733mL1.7466mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存⽅式和期限。体内实验请根据您的实验动物和给药⽅式选择适当的溶解⽅案，配制前请先配制澄的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的⼯作液，建议您现⽤现配，当天使⽤；澄的储备液可以根据储存条件，适当保存；以下溶剂前的百分⽐指该溶剂在您配制终溶液中的体积占⽐)：1.请依序添加每种溶剂：10%DMSO>>40%PEG300>>5%Tween-80>>45%salineSolubility:5mg/mL(8.73mM);Suspendedsolution;NeedultrasonicBIOLOGICALACTIVITY⽣物活性CH-0793076(TP3076)TFA，喜树碱的六环类似物，TP300的活性药物和主代谢物。CH-0793076TFA抑1/2MasterofSmallMolecules—您⾝边的抑制剂⼤师www.MedChemE制DNA拓扑异构酶I(DNAtopoisomeraseI)，IC50为2.3μM。CH-0793076TFA对表达BCRP(乳腺癌耐药蛋⽩)的细胞也有活性。IC50&TargetTopoisomeraseI2.3μM(IC50)体外研究CH0793076(TP3076)TFA(6daysat37°C)showsantiproliferativeactivityagainstPC-6/BCRPandPC-6/pRCcells,withIC50sof0.35and0.18nM,respectively[1].REFERENCES[1].EndoM,etal.Awatersolubleprodrugofanovelcamptothecinanalogisefficaciousagainstbreastcancerresistanceprotein-expressingtumorxenografts.CancerChemotherPharmacol.2010Jan;65(2):363-71.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021-589559