Endothelin-2-49-69-human-TFA-Endothelin-2-49-69-human-canine-TFA-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•Agonists•ScreeningLibrarieswww.MedChemEEndothelin-2(49-69),humanTFACat.No.:HY-P0207ASynonyms:Endothelin-2(49-69)(human,canine)TFA;Humanendothelin-2TFA分⼦式:C₁₁₇H₁₆₁N₂₆F₃O₃₄S₄分⼦量:2660.94Sequence:Cys-Ser-Cys-Ser-Ser-Trp-Leu-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp(Disulfidebridge:Cys1-Cys15,Cys3-Cys11)SequenceShortening:CSCSSWLDKECVYFCHLDIIW(Disulfidebridge:Cys1-Cys15,Cys3-Cys11)作⽤靶点:Others作⽤通路:Others储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCOA.BIOLOGICALACTIVITY⽣物活性Endothelin-2(49-69),human(TFA)(Endothelin-2(49-69)(human,canine)(TFA))由21个氨酸组成的⾎管活性肽，可与G蛋⽩连接的跨膜受体，ET-RA和ET-RB结合。体外研究Atnanomolarconcentrations,Endothelin-2exhibitsastrongandlong-lastingvasoconstrictoractivitycharacteristicofendothelin(EC50=0.52nM)[1].Endothelin-2isachemoattractantformacrophagesandTHP-1monocyticcells,butnotforfreshlyisolatedmonocytes.ThechemotacticresponsetoEndothelin-2showsatypicalbell-shapedresponsecurve.ExperimentswithendothelinreceptorantagonistsshowsthatmigrationtoEndothelin-2ismediatedviatheET-RBreceptor.Endothelin-2expressionbytumorsmaymodulatethebehaviorofmacrophagessuchthatactivatedcellsaccumulateinareasofhypoxia[2].体内研究TwodistinctphasesofpressoreffectsaretypicallyseeninresponsetoEndothelin-2:theearlyphaseimmediatelyfollowsthedepressorresponseanddominatesduringthenext3-10min,whereasthelatepressoreffectdevelops10-20minaftertheinjectionandlasts>1hr[1].REFERENCES1/2MasterofSmallMolecules—您⾝边的抑制剂⼤师www.MedChemE[1].GrimshawMJ,etal.Endothelin-2isamacrophagechemoattractant:implicationsformacrophagedistributionintumors.EurJImmunol.2002Sep;32(9):2393-400.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-82