Ferrous-bisglycinate-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•Agonists•ScreeningLibrarieswww.MedChemEFerrousbisglycinateCat.No.:HY-130078CASNo.:20150-34-9分⼦式:C₄H₆FeN₂O₄分⼦量:201.95作⽤靶点:Others作⽤通路:Others储存⽅式:4°C,protectfromlight,storedundernitrogen*Insolvent:-80°C,6months;-20°C,1month(protectfrom

light,storedundernitrogen)溶解性数据体外实验H2O:35.71mg/mL(176.83mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制备储备液1mM4.9517mL24.7586mL49.5172mL5mM0.9903mL4.9517mL9.9034mL10mM0.4952mL2.4759mL4.9517mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存⽅式和期限。BIOLOGICALACTIVITY⽣物活性Ferrousbisglycinate⼀种具有⼝服活性的铁强化剂和补充剂。Ferrousbisglycinate可⽤于缺铁性贫⾎的研究。体外研究Ferrousbisglycinate(25-200μM;2h)doesnotaffecttheCaco-2cellsviability[2].Ferrousbisglycinate(25μM;2h)increasesferritincontentintheCaco-2cells[2].CellViabilityAssay[2]CellLine:Caco-2cells1/2MasterofSmallMolecules—您⾝边的抑制剂⼤师www.MedChemEConcentration:0,25,50,100,200μMIncubationTime:2hoursResult:Didnotaffecttheviabilityofwild-typeanddivalentmetaltransporter1(DMT1)knockoutCaco-2cells.WesternBlotAnalysis[2]CellLine:Caco-2cellsConcentration:25μMIncubationTime:2hoursResult:IncreasedferritincontentanddecreasedDMT1expressionlevelssignificantlyinthewild-typecells.体内研究Ferrousbisglycinate(500mg/kgiron;p.o.)exertsaprotectiveeffectoncolitisinmice[3].AnimalModel:FemaleC57BL/6miceareinducedcolitisbydextransodiumsulfate(DSS)[3]Dosage:500mg/kgironAdministration:P.o.(addtothediet)for10daysResult:Hadthebestsurvivalrates(100%).Causedtheleastbodylost(9%bodyloss).REFERENCES[1].FerrariP,et,al.Treatmentofmildnon-chemotherapy-inducedirondeficiencyanemiaincancerpatients:comparisonbetweenoralferrousbisglycinatechelateandferroussulfate.BiomedPharmacother.2012Sep;66(6):414-8.[2].YuX,et,al.IronTransportfromFerrousBisglycinateandFerrousSulfateinDMT1-KnockoutHumanIntestinalCaco-2Cells.Nutrients.2019Feb26;11(3):485.[3].ConstanteM,et,al.IronSupplementsModulateColonMicrobiotaCompositionandPotentiatetheProtectiveEffectsofProbioticsinDextranSodiumSulfate-inducedColitis.InflammBowelDis.2017May;23(5):753-766.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresea