L-Alanyl-L-glutamine-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•Agonists•ScreeningLibrarieswww.MedChemEL-Alanyl-L-glutamineCat.No.:HY-W014102CASNo.:39537-23-0分⼦式:C₈H₁₅N₃O₄分⼦量:217.22作⽤靶点:EndogenousMetabolite作⽤通路:MetabolicEnzyme/Protease储存⽅式:4°C,protectfromlight*Insolvent:-80°C,6months;-20°C,1month(protectfrom

light)溶解性数据体外实验H2O:100mg/mL(460.36mM;Needultrasonic)DMSO:<1mg/mL(insolubleorslightlysoluble)MassSolvent1mg5mg10mgConcentration制备储备液1mM4.6036mL23.0181mL46.0363mL5mM0.9207mL4.6036mL9.2073mL10mM0.4604mL2.3018mL4.6036mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存⽅式和期限。BIOLOGICALACTIVITY⽣物活性L-Alanyl-L-glutamine⼀种⾕氨酰胺⼆肽，对抗氧化系统有益，可减轻炎症，并可能在分解代谢情况下调节热休克蛋⽩(HSP)的反应。IC50&TargetHumanEndogenousMetabolite体外研究L-Alanyl-L-glutamine(2mM;24hours)partiallyorfullyattenuateschronicinsulinsecretion,andIR-βandCOXIVlevelswhicharedecreasedwhenβ-cellswereexposedtomacrophagesfollowingstimulationinvitro(IMMs)[1].1/2MasterofSmallMolecules—您⾝边的抑制剂⼤师www.MedChemEL-Alanyl-L-glutamine-dependentβ-cellprotectionmediatedbycoordinatedeffectsontheglutamine-GSHaxis,andtheHSPpathway,maintenanceofmitochondrialmetabolismandstimulus-secretioncouplingessentialforinsulinrelease[1].REFERENCES[1].CruzatVF,etal.Alanyl-glutamineimprovespancreaticβ-cellfunctionfollowingexvivoinflammatorychallenge.JEndocrinol.2015Mar;224(3):261-71.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792/p>