Nicotredole-Tryptamide-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•Agonists•ScreeningLibrarieswww.MedChemENicotredoleCat.No.:HY-137394CASNo.:29876-14-0Synonyms:Tryptamide分⼦式:C₁₆H₁₅N₃O分⼦量:265.31作⽤靶点:Others作⽤通路:Others储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCOA.溶解性数据体外实验DMSO:25mg/mL(94.23mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制备储备液1mM3.7692mL18.8459mL37.6918mL5mM0.7538mL3.7692mL7.5384mL10mM0.3769mL1.8846mL3.7692mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存⽅式和期限。体内实验请根据您的实验动物和给药⽅式选择适当的溶解⽅案，配制前请先配制澄的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的⼯作液，建议您现⽤现配，当天使⽤；澄的储备液可以根据储存条件，适当保存；以下溶剂前的百分⽐指该溶剂在您配制终溶液中的体积占⽐)：1.请依序添加每种溶剂：10%DMSO>>40%PEG300>>5%Tween-80>>45%salineSolubility:≥2.08mg/mL(7.84mM);Clearsolution2.请依序添加每种溶剂：10%DMSO>>90%(20%SBE-β-CDinsaline)Solubility:≥2.08mg/mL(7.84mM);Clearsolution3.请依序添加每种溶剂：10%DMSO>>90%cornoilSolubility:≥2.08mg/mL(7.84mM);Clearsolution1/2MasterofSmallMolecules—您⾝边的抑制剂⼤师www.MedChemEBIOLOGICALACTIVITY⽣物活性Nicotredole(Tryptamide)⼀种⼝服活性的消炎镇痛剂。Nicotredole显⽰出与Phenylbutazone相当的明显抗炎作⽤。Nicotredole仅具有弱的致溃疡活性。体外研究Nicotredoleinhibitsprostaglandinsynthetaseactivityinvitro[1].体内研究Nicotredoleproducesantiinflammatoryeffectsincarrageenin-inducedratpawoedema[1].Nicotredolereversespyrogen-inducedhyperthermiainrats,elicitsanalgesiceffectsinrats,prolongsthetimeofhexobarbitalsleepinratsandinhibitslocomotoractivityinratsandmice[1].Nicotredole(i.p.)hasLD50sof1260mg/kgand1980mg/kgformaleratsandmalemice,respectively[1].Nicotredole(p.o.)hasLD50sof8.5g/kgand9.3g/kgformaleratsandmalemice,respectively[1].Nicotredole(25mg/kg;p.o.ori.p.)undergoesfastabsorption(t1/2=4.92-17.5min)andelimination(t1/2=55.72-74.52min),canreachCmax(11-13μg/cm3)after30min,andgivesAUCvaluesintherangeof21.40-27.30(μg•h/cm3)[2].REFERENCES[1].HermanZS,et,al.Basicpharmacologicalpropertiesofanovelantiinflammatorydrugtryptamide.PolJPharmacolPharm.Nov-Dec1987;39(6):729-36.[2].SzumiłoH.Pharmacokineticsoftryptamidefollowingoralandintraperitonealadministrationinrats.ActaPolPharm.1990;47(1-2):19-22.[3].KuligD,et,al.Acomparisonofanti-inflammatory,analgesicandulcerogenicactionoftryptamide,ibuprofenandpiroxicam.PolJPharmacolPharm.Nov-Dec1987;39(6):769-72.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.For