EMAC10101d-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEEMAC10101dCat.No.:HY-138365CASNo.:2561476-24-0分⼦式:C₁₇H₁₅Cl₂N₃O₂S₂分⼦量:428.36作⽤靶点:CarbonicAnhydrase作⽤通路:MetabolicEnzyme/Protease储存⽅式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性数据体外实验DMSO:62.5mg/mL(145.91mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制备储备液1mM2.3345mL11.6724mL23.3449mL5mM0.4669mL2.3345mL4.6690mL10mM0.2334mL1.1672mL2.3345mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。体内实验请根据您的实验动物和给药⽅式选择适当的溶解⽅案。以下溶解⽅案都请先按照InVitro⽅式配制澄的储备液，再依次添加助溶剂：(为保证实验结果的可靠性，澄的储备液可以根据储存条件，适当保存；体内实验的⼯作液，建议您现⽤现配，当天使⽤；以下溶剂前显⽰的百分⽐指该溶剂在您配制终溶液中的体积占⽐；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的⽅式助溶)1.请依序添加每种溶剂：10%DMSO>>90%cornoilSolubility:≥2.08mg/mL(4.86mM);Clearsolution1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemEBIOLOGICALACTIVITY⽣物活性EMAC10101d有效的、选择性的hCAII抑制剂，其Ki值为8.1nM。体外研究EMAC10101dexhibitsKivaluesof9627.4nM,8.1nM,224.6nMand154.9nMforhCAⅠ,hCAII,hCAⅨandhCAⅫ,respectively[1].REFERENCES[1].RitaMeleddu,etal.NewDihydrothiazoleBenzensulfonamides:LookingforSelectivitytowardCarbonicAnhydraseIsoformsI,II,IX,andXII.ACSMedChemLett.2020Feb13;11(5):852-856.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792ax: