FAPI-46-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEFAPI-46Cat.No.:HY-137331CASNo.:2374782-04-2分⼦式:C₄₁H₅₇F₂N₁₁O₉分⼦量:885.96作⽤靶点:Others作⽤通路:Others储存⽅式:4°C,sealedstorage,awayfrommoisture*Insolvent:-80°C,6months;-20°C,1month(sealed

storage,awayfrommoisture)溶解性数据体外实验DMSO:100mg/mL(112.87mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制备储备液1mM1.1287mL5.6436mL11.2872mL5mM0.2257mL1.1287mL2.2574mL10mM0.1129mL0.5644mL1.1287mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month(sealedstorage,awayfrommoisture)。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。体内实验请根据您的实验动物和给药⽅式选择适当的溶解⽅案。以下溶解⽅案都请先按照InVitro⽅式配制澄的储备液，再依次添加助溶剂：(为保证实验结果的可靠性，澄的储备液可以根据储存条件，适当保存；体内实验的⼯作液，建议您现⽤现配，当天使⽤；以下溶剂前显⽰的百分⽐指该溶剂在您配制终溶液中的体积占⽐；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的⽅式助溶)1.请依序添加每种溶剂：10%DMSO>>40%PEG300>>5%Tween-80>>45%salineSolubility:≥5mg/mL(5.64mM);Clearsolution2.请依序添加每种溶剂：10%DMSO>>90%(20%SBE-β-CDinsaline)Solubility:≥5.75mg/mL(6.49mM);Clearsolution1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemEBIOLOGICALACTIVITY⽣物活性FAPI-46⼀种于喹啉的靶向成纤维细胞活化蛋⽩(FAP)的放射性⽰踪剂。FAPI-46具有更⾼的肿瘤吸收率和增长的肿瘤积累时间。FAPI-46可⽤于多种不同癌症的肿瘤成像。IC50&Targetfibroblastactivationprotein(FAP)[1]体外研究FAPI-46(1-24h)robustlybindstohumanFAPinhumanFAP-expressingHT-1080cells[1].体内研究FAPI-46(i.v.)showsimprovedratiosoftumortoliver,kidney,andbrainuptake,resultinginanenhancedimagecontrastforPETimaging[1].REFERENCES[1].LoktevA,et,al.DevelopmentofFibroblastActivationProtein-TargetedRadiotracerswithImprovedTumorRetention.JNuclMed.2019Oct;60(10):1421-1429.[2].MoonES,et,al.Targetingfibroblastactivationprotein(FAP):nextgenerationPETradiotracersusingsquaramidecoupledbifunctionalDOTAandDATA5mchelators.EJNMMIRadiopharmChem.2020Jul29;5(1):19.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-