TH1338-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemETH1338Cat.No.:HY-120574CASNo.:1258494-60-8分⼦式:C₂₂H₂₁N₃O₄分⼦量:391.42作⽤靶点:Others作⽤通路:Others储存⽅式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性数据体外实验DMSO:10mg/mL(25.55mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制备储备液1mM2.5548mL12.7740mL25.5480mL5mM0.5110mL2.5548mL5.1096mL10mM0.2555mL1.2774mL2.5548mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。体内实验请根据您的实验动物和给药⽅式选择适当的溶解⽅案。以下溶解⽅案都请先按照InVitro⽅式配制澄的储备液，再依次添加助溶剂：(为保证实验结果的可靠性，澄的储备液可以根据储存条件，适当保存；体内实验的⼯作液，建议您现⽤现配，当天使⽤；以下溶剂前显⽰的百分⽐指该溶剂在您配制终溶液中的体积占⽐；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的⽅式助溶)1.请依序添加每种溶剂：10%DMSO>>90%(20%SBE-β-CDinsaline)Solubility:≥1.82mg/mL(4.65mM);Clearsolution1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemEBIOLOGICALACTIVITY⽣物活性TH1338(compound3b)具有⼝服活性的喜树碱的衍⽣物，有潜⼒的抗癌化合物，在体外表现出优异的肿瘤细胞毒性的效果。TH1338(compound3b)具有显著的⾎脑屏障透过性，良好的外排泵特性和低⾎液学毒性。体外研究TH1338(compound3b)demonstratessignificantbrainpenetrationwhendosedorallyinmice[1].TH1338(compound3b)exhibitspotentanti-tumoractivityinH460(NSCLC)humantumorxenograftmodel[1].CellViabilityAssay[1]CellLine:H460(NSCLC)humantumorxenograftmodel.Concentration:40mg/kg.IncubationTime:Oralgavage.Result:Exhibitedsuperiorantitumoractivity.REFERENCES[1].Jian-XinDuan,etal.14-Aminocamptothecins:theirsynthesis,preclinicalactivity,andpotentialuseforcancertreatment.JMedChem.2011Mar24;54(6):1715-23.[2].XiaCheng,etal.Preparation,Characterization,andInVivoStudyof7-Ethyl-14-Aminocamptothecin-LoadedPoly(EthyleneGlycol)2000-Poly(LacticAcid)2000PolymericMicellesAgainstH460HumanNonsmallCellLungCarcinoma.JPharmSci.2015Nov;104(11):3934-3942.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-8