HDAC8-IN-3-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEHDAC8-IN-3Cat.No.:HY-147934CASNo.:2432825-93-7分⼦式:C₁₈H₁₂N₄O₃S₂分⼦量:396.44作⽤靶点:HDAC;Apoptosis作⽤通路:CellCycle/DNADamage;Epigenetics;Apoptosis储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性HDAC8-IN-3(compoundP19)⼀种有效的HDAC8抑制剂，其IC50值为9.3μM，可产⽣热稳定性。HDAC8-IN-3具有细胞毒性并诱导⽩⾎病细胞系凋亡。IC50&TargetHDAC8HDAC4HDAC1HDAC29.3μM(IC50)＞50μM(IC50)＞50μM(IC50)41μM(IC50)HDAC3HDAC5HDAC6HDAC8＞50μM(IC50)＞50μM(IC50)＞50μM(IC50)17μM(IC50)体外研究HDAC8-IN-3(compoundP19)(5-200μM,48hours;HEK293Tcells)hascytotoxicityinleukemiccelllines[1].HDAC8-IN-3(compoundP19)(50μM)inhibitsglucosetransporter1(GLUT1)-mediatedglucosetransportbydown-regulatingGLUT1expression(IC50=28.2μM)[1].HDAC8-IN-3(compoundP19)(79.9μM;24hours)caninduceapoptoticdeathintheCEMcellline[1].CellCytotoxicityAssay[1]CellLine:K562,KCL22andCEMleukemiacells.Concentration:50μMIncubationTime:48hoursResult:InhibitedwithIC50valuesof79.9,85.4and43.2μMforCEM,K562andKCL22cells,respectively.1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemEApoptosisAnalysis[1]CellLine:CEMcellsConcentration:79.9μMIncubationTime:24hoursResult:Thepercentageofapoptoticcellswasrecordedas60.97%.REFERENCES[1].UpadhyayN,etal.DiscoveryofnovelN-substitutedthiazolidinediones(TZDs)asHDAC8inhibitors:in-silicostudies,synthesis,andbiologicalevaluation.BioorgChem.2020Jul;100:103934.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021-58