Acloproxalap-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEAcloproxalapCat.No.:HY-147240CASNo.:1824609-67-7分⼦式:C₁₂H₁₄N₂O分⼦量:202.25作⽤靶点:Others作⽤通路:Others储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性Acloproxalap⼀种于喹啉的醛除剂，可⽤于有毒醛积累的疾病研究，如眼部、⽪肤等炎症性疾病，肺炎等呼吸系统疾病，器官疾病以及病毒感染相关性综合症等。体内研究Acloproxalap(compoundI-6)(100or200mg/kg,i.p.orp.o.,everyday,6days)caneffectivelyimproveinflammationofthecoloninacuteulcerativecolitis(UC)femaleSwissWebstermice[1].AnimalModel:Acuteulcerativecolitis(UC)infemaleSwissWebstermice[1]Dosage:100mg/kg,200mg/kgAdministration:Intraperitonealinjectionfor100mg/kg,oralgavagefor200mg/kg;everyday;6daysResult:Inhibitedweightlossinintraperitonealinjectionmicesignificantlywhiletherewasnosignificantdifferenceintheoralgavagegroupcomparedtothecontrolgroup.Bothsignificantlyreducedcolonichistopathologicalparameters.AnimalModel:Malenon-naïvebeagledogs[2]Dosage:3mg/kgAdministration:Intravenousinjection;onceResult:ThepharmacokineticparametersofAcloproxalap(compoundI-1)ParameterAcloproxalap(compoundI-1)t1/21.82hTmax0.518hClearance12.21/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemEmL/kg/minsteady-statevolume1385mL/kgAUC0-t4103ng/mL*hAUC0‑inf_obs4137ng/mL*hAnimalModel:Malenon-naïvebeagledogs[2]Dosage:10mg/kgAdministration:Oralgavage;onceResult:ThepharmacokineticparametersofAcloproxalap(compoundI-1)ParameterAcloproxalap(compoundI-1)t1/23.02hTmax0.518hCmax3558ng/mLAUC0-t9361ng/mL*hAUC0‑inf_obs9546ng/mL*hBioA75%REFERENCES[1].SusanMacdonald,etal.Treatmentofinflammatorydisorders.US20190105322[2].ToddBrady,etal.Pharmaceuticalformulationsandusesthereof.WO2021231792McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-