Arg-9-acetate-Nona-L-arginine-acetate-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemE(Arg)9acetateCat.No.:HY-P0133BSynonyms:Nona-L-arginineacetate;PeptideR9acetate分⼦式:C₅₆H₁₁₄N₃₆O₁₂分⼦量:1483.74SequenceShortening:RRRRRRRRR作⽤靶点:Others作⽤通路:Others储存⽅式:Protectfromlight,storedundernitrogenPowder-80°C2years-20°C1yearInsolvent-80°C6months-20°C1monthBIOLOGICALACTIVITY⽣物活性(Arg)9(Nona-L-arginine)acetate⼀种由9个精氨酸残组成的细胞穿透肽(CPP)。(Arg)9acetate具有神经保护功能，在⾕氨酸模型中IC50值为0.78μM。IC50&TargetIC50:0.78μM(neuroprotection)[1]体外研究(Arg)9(Nona-L-arginine;5-10μM)acetateprovidessignificantneuroprotectioninadose–responsemannerfollowingglutamicacidexposure(IC50=0.78μM).Followingkainicacidexposure,(Arg)9acetateisneuroprotective,butlesseffectivethanintheglutamicacidmodel(IC50=0.81μM).(Arg)9acetatealsoshowsneuroprotectionfollowinginvitroischemia(IC50=6μM)[1].体内研究(Arg)9(Nona-L-arginine;1ꢀμM/kg(600ꢀμL);i.v.;once,for30min;maleSprague–Dawleyratspermanentmiddlecerebralarterystrokemodel)acetateshowsneuroprotectiveeffectsandreducesinfarctvolume[2].AnimalModel:MaleSprague–Dawleyrats(270to320ꢀg)permanentmiddlecerebralarterystrokemodel[2]Dosage:1μM/kg(600ꢀμL)1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemEAdministration:Intravenousinjection;once,over5minutesResult:Reducedsignificantiy20%ininfarctvolume.户使⽤本产品发表的科研⽂献•InVitroCellDevBiol-Pl.06January2022.Seemorecustomervalidationsonwww.MedChemEMcePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021-58955