Vps34-IN-1-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEVps34-IN-1Cat.No.:HY-12795CASNo.:1383716-33-3分⼦式:C₂₁H₂₄ClN₇O分⼦量:425.91作⽤靶点:PI3K;Autophagy作⽤通路:PI3K/Akt/mTOR;Autophagy储存⽅式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性数据体外实验DMSO:≥31mg/mL(72.79mM)*"≥"meanssoluble,butsaturationunknown.MassSolvent1mg5mg10mgConcentration制备储备液1mM2.3479mL11.7396mL23.4791mL5mM0.4696mL2.3479mL4.6958mL10mM0.2348mL1.1740mL2.3479mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。体内实验请根据您的实验动物和给药⽅式选择适当的溶解⽅案。以下溶解⽅案都请先按照InVitro⽅式配制澄的储备液，再依次添加助溶剂：(为保证实验结果的可靠性，澄的储备液可以根据储存条件，适当保存；体内实验的⼯作液，建议您现⽤现配，当天使⽤；以下溶剂前显⽰的百分⽐指该溶剂在您配制终溶液中的体积占⽐；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的⽅式助溶)1.请依序添加每种溶剂：10%DMSO>>40%PEG300>>5%Tween-80>>45%saline1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemESolubility:≥2.5mg/mL(5.87mM);Clearsolution2.请依序添加每种溶剂：10%DMSO>>90%(20%SBE-β-CDinsaline)Solubility:≥2.5mg/mL(5.87mM);Clearsolution3.请依序添加每种溶剂：10%DMSO>>90%cornoilSolubility:≥2.5mg/mL(5.87mM);ClearsolutionBIOLOGICALACTIVITY⽣物活性Vps34-IN-1Vps34的抑制剂，来⾃从专利WO2012085815A1，化合物实例16a，IC50为4nM。Vps34-IN-1调节⾃噬(autophagy)。IC50&TargetVps344nM(IC50)户使⽤本产品发表的科研⽂献•JExpClinCancerRes.2018Jun25;37(1):122.•PlantCellRep.2022Jan3.•Oncotarget.2016Aug16;7(33):53515-53525.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].IvanCornellaTaracido,etal.Bi-heteroarylcompoundsasvps34inhibitors.WO2012085815A1.[2].LimpertAS,etal.AutophagyinCancer:RegulationbySmallMolecules.TrendsPharmacolSci.2018Dec;39(12):1021-1032McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792