K-Ras-G12C-inhibitor-12-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEK-Ras(G12C)inhibitor12Cat.No.:HY-18707CASNo.:1469337-95-8分⼦式:C₁₅H₁₇ClIN₃O₃分⼦量:449.67作⽤靶点:Ras;Apoptosis作⽤通路:GPCR/GProtein;Apoptosis储存⽅式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性数据体外实验DMSO:16.67mg/mL(37.07mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制备储备液1mM2.2239mL11.1193mL22.2385mL5mM0.4448mL2.2239mL4.4477mL10mM0.2224mL1.1119mL2.2239mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。体内实验请根据您的实验动物和给药⽅式选择适当的溶解⽅案。以下溶解⽅案都请先按照InVitro⽅式配制澄的储备液，再依次添加助溶剂：(为保证实验结果的可靠性，澄的储备液可以根据储存条件，适当保存；体内实验的⼯作液，建议您现⽤现配，当天使⽤；以下溶剂前显⽰的百分⽐指该溶剂在您配制终溶液中的体积占⽐；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的⽅式助溶)1.请依序添加每种溶剂：10%DMSO>>40%PEG300>>5%Tween-80>>45%salineSolubility:≥1.67mg/mL(3.71mM);Clearsolution1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemE2.请依序添加每种溶剂：10%DMSO>>90%(20%SBE-β-CDinsaline)Solubility:≥1.67mg/mL(3.71mM);ClearsolutionBIOLOGICALACTIVITY⽣物活性K-Ras(G12C)inhibitor12K-Ras(G12C)抑制剂,K-Ras(G12C)inhibitor12作⽤于H1792细胞,EC50为0.32μM。REFERENCES[1].OstremJM,etal.K-Ras(G12C)inhibitorsallostericallycontrolGTPaffinityandeffectorinteractions.Nature.2013Nov28;503(7477):548-551.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792ax: