Quarfloxin-CX-3543-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEQuarfloxinCat.No.:HY-14776CASNo.:865311-47-3Synonyms:CX-3543分⼦式:C₃₅H₃₃FN₆O₃分⼦量:604.67作⽤靶点:DNA/RNASynthesis作⽤通路:CellCycle/DNADamage储存⽅式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性数据体外实验DMSO:5mg/mL(8.27mM;ultrasonicandadjustpHto3withHCl)H2O:1mg/mL(1.65mM;ultrasonicandadjustpHto5with0.1MHCL)DMSO:1mg/mL(1.65mM;ultrasonicandwarmingandheatto60°C)MassSolvent1mg5mg10mgConcentration制备储备液1mM1.6538mL8.2690mL16.5379mL5mM0.3308mL1.6538mL3.3076mL10mM---------请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。BIOLOGICALACTIVITY⽣物活性Quarfloxin(CX-3543)⼀种具有抗肿瘤活性的氟喹诺酮类衍⽣物，其靶向抑制RNApolI的活性，在神经母细1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemE胞瘤中的IC50值在纳尔级别。Quarfloxin⼲扰核糖体DNA中核蛋⽩与G-四重DNA结构的相互作⽤[1]。IC50&TargetRNApolI[1].体外研究Quarfloxin(CX-3543)effectivelyinhibitsthegrowthofneuroblastomacellsinvitro.MNA(orhighc-Myc)andwt-TP53celllinesarefoundtobemoresensitivetoQuarfloxin.QuarfloxinandinducesDNAdamage,p53signaling,celldeath,andcellcyclearrestinneuroblastomacelllines[1].Solutioninvitro:QuarfloxinissuspendedinDMSOtoastockof10mM[1].户使⽤本产品发表的科研⽂献•CancerRes.2022Jan12;canres.1707.2021.•Biochimie.2022Apr20;199:81-91.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].HaldØH,etal.InhibitorsofribosomebiogenesisrepressthegrowthofMYCN-amplifiedneuroblastoma.Oncogene.2018Dec12.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021