Hydrocortisone-hemisuccinate-Hydrocortisone-21-hemisuccinate-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEHydrocortisonehemisuccinateCat.No.:HY-B1402CASNo.:2203-97-6Synonyms:Hydrocortisone21-hemisuccinate分⼦式:C₂₅H₃₄O₈分⼦量:462.53作⽤靶点:GlucocorticoidReceptor;InterleukinRelated作⽤通路:Immunology/Inflammation储存⽅式:Powder-20°C3yearsInsolvent-80°C6months-20°C1month溶解性数据体外实验DMSO:250mg/mL(540.51mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制备储备液1mM2.1620mL10.8101mL21.6202mL5mM0.4324mL2.1620mL4.3240mL10mM0.2162mL1.0810mL2.1620mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。体内实验请根据您的实验动物和给药⽅式选择适当的溶解⽅案。以下溶解⽅案都请先按照InVitro⽅式配制澄的储备液，再依次添加助溶剂：(为保证实验结果的可靠性，澄的储备液可以根据储存条件，适当保存；体内实验的⼯作液，建议您现⽤现配，当天使⽤；以下溶剂前显⽰的百分⽐指该溶剂在您配制终溶液中的体积占⽐；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的⽅式助溶)1.请依序添加每种溶剂：10%DMSO>>40%PEG300>>5%Tween-80>>45%salineSolubility:≥2.08mg/mL(4.50mM);Clearsolution1/3MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemE2.请依序添加每种溶剂：10%DMSO>>90%(20%SBE-β-CDinsaline)Solubility:≥2.08mg/mL(4.50mM);Clearsolution3.请依序添加每种溶剂：10%DMSO>>90%cornoilSolubility:≥2.08mg/mL(4.50mM);ClearsolutionBIOLOGICALACTIVITY⽣物活性Hydrocortisonehemisuccinate(Hydrocortisone21-hemisuccinate)，⼀种糖⽪质激素，⼝服活性的甾体抗炎剂(SAID)。Hydrocortisonehemisuccinate抑制IL-6和IL-3的⽣物活性，IC50值分别为6.7和21.4μM。Hydrocortisonehemisuccinate可⽤于溃疡性结肠炎(UC)的研究。IC50&TargetIL-3IL-6IL-6IL-36.7μM(IC50)21.4μM(IC50)体外研究HydrocortisonehemisuccinateinhibitsIL-6andIL-3bioactivity,withIC50sof6.7and21.4μM,respectively,andshowsnocytotoxiceffectsonIL-6-independentMH60cells[3].Hydrocortisonehemisuccinate(0.12-60μM;72h)inhibitsphytohemagglutinin(PHA)responseinperipherallymphocytes(PBL)andT-lymphocytescultures[3].体内研究Hydrocortisonehemisuccinate(30mg/kg;p.o.twicedailyfor5d)reducestheweightlossandincreasesthefoodintakeinmice[2].AnimalModel:MaleSprague-Dawleyrats(200-220g,10-11weeks)areinducedcolitis[2]Dosage:30mg/kgAdministration:P.o.twicedailyfor5daysResult:Significantlydecreasedthediseaseactivityindex(DAI)scoresandmyeloperoxidase(MPO)activitycomparedtothe2,4,6-trinitrobenzenesulfonicacid(TNBS)group.Increasedthebodyweight.户使⽤本产品发表的科研⽂献•BiomedPharmacother.2022Jun7;152:113243.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].KangBS,et,al.Inhibitoryeffectsofanti-inflammatorydrugsoninterleukin-6bioactivity.BiolPharmBull.2001Jun;24(6):701-3.[2].YouYC,et,al.InvitroandinvivoapplicationofpH-sensitivecolon-targetingpolysaccharidehydrogelusedforulcerativecolitistherapy.CarbohydrPolym.2015Oct5;130:243-53.2/3MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemE[3].LanghoffE,et,al.Theimmunosuppressivepotencyinvitroofphysiologicalandsyntheticsteroidsonlymphocytecultures.IntJImmunopharmacol.1987;9(4):469-73.McePdfHeightCaution:Producthasnotbeenfullyvalidatedf