D-plus-Galactosamine-hydrochloride-D-Galactosamine-hydrochloride-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemED(+)-GalactosaminehydrochlorideCat.No.:HY-42682CASNo.:1772-03-8Synonyms:D-Galactosaminehydrochloride分⼦式:C₆H₁₄ClNO₅分⼦量:215.63作⽤靶点:Others作⽤通路:Others储存⽅式:4°C,sealedstorage,awayfrommoisture*Insolvent:-80°C,6months;-20°C,1month(sealed

storage,awayfrommoisture)溶解性数据体外实验H2O:100mg/mL(463.76mM;Needultrasonic)DMSO:50mg/mL(231.88mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制备储备液1mM4.6376mL23.1879mL46.3757mL5mM0.9275mL4.6376mL9.2751mL10mM0.4638mL2.3188mL4.6376mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month(sealedstorage,awayfrommoisture)。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。体内实验请根据您的实验动物和给药⽅式选择适当的溶解⽅案。以下溶解⽅案都请先按照InVitro⽅式配制澄的储备液，再依次添加助溶剂：(为保证实验结果的可靠性，澄的储备液可以根据储存条件，适当保存；体内实验的⼯作液，建议您现⽤现配，当天使⽤；以下溶剂前显⽰的百分⽐指该溶剂在您配制终溶液中的体积占⽐；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的⽅式助溶)1.请依序添加每种溶剂：10%DMSO>>40%PEG300>>5%Tween-80>>45%saline1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemESolubility:≥2.5mg/mL(11.59mM);Clearsolution2.请依序添加每种溶剂：10%DMSO>>90%(20%SBE-β-CDinsaline)Solubility:≥2.5mg/mL(11.59mM);Clearsolution3.请依序添加每种溶剂：10%DMSO>>90%cornoilSolubility:≥2.5mg/mL(11.59mM);Clearsolution4.请依序添加每种溶剂：PBSSolubility:100mg/mL(463.76mM);Clearsolution;NeedultrasonicBIOLOGICALACTIVITY⽣物活性D(+)-Galactosamine(D-Galactosamine)hydrochloride⼀种已确定的实验毒素，主通过产⽣⾃由和UTP核苷酸的消耗引起肝损伤。D(+)-Galactosaminehydrochloride中毒也会导致肾功能不全，所以，肾功能衰竭通常和终末期肝损伤有关。脂多糖/D(+)-Galactosamine诱导的急性肝损伤⼀种已知的发性肝衰竭动物模型。REFERENCES[1].AyhanciA,etal.ProtectiveeffectsofellagicacidinD-galactosamine-inducedkidneydamageinrats.Cytotechnology.2016;68(5):1763-1770.[2].OkumuraA,etal.Alleviationoflipopolysaccharide/d-galactosamine-inducedliverinjuryinleukocytecell-derivedchemotaxin2deficientmice.BiochemBiophysRep.2017;12:166-171.Published2017Oct13.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel: