KKL-10-DataSheet-生命科学试剂-MedChemExpressVIP

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEKKL-10Cat.No.:HY-101865CASNo.:952849-76-2分⼦式:C₁₄H₁₀BrN₃O₂S分⼦量:364.22作⽤靶点:Bacterial作⽤通路:Anti-infection储存⽅式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性数据体外实验DMSO:2.78mg/mL(7.63mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制备储备液1mM2.7456mL13.7280mL27.4559mL5mM0.5491mL2.7456mL5.4912mL10mM---------请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。BIOLOGICALACTIVITY⽣物活性KKL-10⼀种具有⼴谱抗活性的⼩分⼦核糖体拯救抑制剂。体外研究TheribosomerescueinhibitorKKL-10exhibitsexceptionalantimicrobialactivityagainstbothattenuatedandfullyvirulentstrainsofF.tularensis.Theminimuminhibitoryconcentration(MIC)againstF.tularensisstrainLVSandSchuS4are0.12and0.48μg/mL,respectively.KKL-10arrestsintracellulargrowthofF.tularensis1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemEduringallstagesofinfection.KKL-10doesnotaffectmacrophageviabilityorfunction.KKL-10producescytotoxiceffectsoflessthan5%atconcentrationsupto17.5μg/mL.ThecombinationofIFN-γstimulationandKKL-10activityresultsinareductionofthebacterialloadby>99.9%.KKL-10isalsoabletoinhibitgrowthofF.tularensisinsideeukaryoticcellsandshownotoxicitytoHepG2cells[1].REFERENCES[1].GoralskiTD,etal.InhibitorsofRibosomeRescueArrestGrowthofFrancisellatularensisatAllStagesofIntracellularReplication.AntimicrobAgentsChemother.2016May23;60(6):3276-82.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021-5