S-MCPG-plus-MCPG-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemE(S)-MCPGCat.No.:HY-100406CASNo.:150145-89-4Synonyms:(+)-MCPG分⼦式:C₁₀H₁₁NO₄分⼦量:209.2作⽤靶点:mGluR作⽤通路:GPCR/GProtein;NeuronalSignaling储存⽅式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性数据体外实验DMSO:1mg/mL(4.78mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制备储备液1mM4.7801mL23.9006mL47.8011mL5mM---------10mM---------请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。BIOLOGICALACTIVITY⽣物活性(S)-MCPG((+)-MCPG)⼀种有效的I/II类代谢型⾕氨酸受体(mGluRs)拮抗剂，(RS)-MCPG(HY-100371)的活性异构体。(S)-MCPG可⽤于mGluRs在空间学习中的作⽤研究。IC50&TargetmGluR1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemE体外研究(S)-MCPG(100μM)hasnodetectableeffectsonbasalspineformationoreliminationmechanismsinWTslicecultures.(S)-MCPGpreventstheincreaseinspineturnovertriggeredbyTBSandinterfereswiththemechanismsofactivity-dependentspinestabilizationinHippocampalslicecultures[1].体内研究MCPG(intraventricularinjection;20μg)treatedratareslowertolearnthetaskandtakeslongertoreachtheplatformthanvehicleinjectedanimals.Ondays2and3,MCPGratshasasignificantlongerescapelatencyandthemeasureofsearcherrorissignificantlylongeroneachofthefirst3days.Onday4,MCPG-treatedanimalsreachesthesamelevelofperformanceascontrolanimalsinMorriswatermaze[2].AnimalModel:MaleLister-HoodedratsinthelearningoftheMorriswatermaze[2]Dosage:20μgAdministration:Intraventricularinjection;20μg;4daysResult:ImpairedtheperformanceofratsinthespatialversionoftheMorriswatermaze,but1/10ofthisdosedidnot.REFERENCES[1].BernadettBoda,etal.Reversalofactivity-mediatedspinedynamicsandlearningimpairmentinamousemodelofFragileXsyndrome.EurJNeurosci.2014Apr;39(7):1130-7.[2].FBordi,etal.EffectsofthemetabotropicglutamatereceptorantagonistMCPGonspatialandcontext-specificlearning.Neuropharmacology.1996;35(11):1557-65.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonl