Corin-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemECorinCat.No.:HY-111048CASNo.:1808113-09-8分⼦式:C₂₆H₂₈N₄O₂分⼦量:428.53作⽤靶点:HistoneDemethylase;HDAC作⽤通路:Epigenetics;CellCycle/DNADamage储存⽅式:4°C,storedundernitrogen*Insolvent:-80°C,6months;-20°C,1month(storedunder

nitrogen)溶解性数据体外实验DMSO:100mg/mL(233.36mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制备储备液1mM2.3336mL11.6678mL23.3356mL5mM0.4667mL2.3336mL4.6671mL10mM0.2334mL1.1668mL2.3336mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month(storedundernitrogen)。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。体内实验请根据您的实验动物和给药⽅式选择适当的溶解⽅案。以下溶解⽅案都请先按照InVitro⽅式配制澄的储备液，再依次添加助溶剂：(为保证实验结果的可靠性，澄的储备液可以根据储存条件，适当保存；体内实验的⼯作液，建议您现⽤现配，当天使⽤；以下溶剂前显⽰的百分⽐指该溶剂在您配制终溶液中的体积占⽐；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的⽅式助溶)1.请依序添加每种溶剂：10%DMSO>>40%PEG300>>5%Tween-80>>45%salineSolubility:≥2.5mg/mL(5.83mM);Clearsolution2.请依序添加每种溶剂：10%DMSO>>90%cornoilSolubility:≥2.5mg/mL(5.83mM);Clearsolution1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemEBIOLOGICALACTIVITY⽣物活性Corin组氨酸赖氨酸特异性去甲化酶(LSD1)和组氨酸脱⼄酰化酶(HDAC)的双重抑制剂，其对LSD1的Ki(inact)值为110nM，对HDAC1的IC50值为147nM。IC50&TargetIC50:147nM(HDAC1),Ki(inact):110nM(LSD1)[1].体外研究Corinisabletoinhibitthedeacetylationofsemisynthetic,reconstitutednucleosomesbytheCoRESTternarycomplex.CorinshowsirreversibleinhibitionofHDAC1activity.InComparisontoMS-275,corinappearstomorepotently(CorinEC5095nMvs.MS-275EC50420nM)andefficaciouslyinducecellularH3K9acetylation.Interestingly,Corin(1μM)isnon-toxictoprimaryhumanmelanocytesincontrasttoMS-275(1μM)[1].户使⽤本产品发表的科研⽂献•NatStructMolBiol.2022Nov7.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].KalinJH,etal.TargetingtheCoRESTcomplexwithdualhistonedeacetylaseanddemethylaseinhibitors.NatCommun.2018Jan4;9(1):53.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel: