CUR61414-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemECUR61414Cat.No.:HY-113965CASNo.:334998-36-6分⼦式:C₃₁H₄₂N₄O₅分⼦量:550.69作⽤靶点:Hedgehog;Smo;Apoptosis作⽤通路:StemCell/Wnt;Apoptosis储存⽅式:Powder-20°C3yearsInsolvent-80°C6months-20°C1month溶解性数据体外实验DMSO:100mg/mL(181.59mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制备储备液1mM1.8159mL9.0795mL18.1590mL5mM0.3632mL1.8159mL3.6318mL10mM0.1816mL0.9080mL1.8159mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。BIOLOGICALACTIVITY⽣物活性CUR61414⼀种新型的可渗透细胞的Hedgehog信号通路抑制剂(IC50=100-200nM)，CUR61414氨脯氨酸类化合物的⼩分⼦成员，可选择性结合Smoothened(Smo)，Ki值为44nM。CUR-61414可以诱导癌细胞凋亡(apoptosis)⽽不会响⾮癌症细胞。IC50&TargetHedgehoginhibitor[1]1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemE体外研究CUR61414isabletoarrestproliferationofbasalcellswithintheBCC-likelesionsandinducecellstoundergoapoptosisresultingincompleteregressionofthelesions,withoutaffectingneighboringskincells[1].体内研究CUR61414causeregressionoftheselesionsinthemice,whichareexposedtoUVlightirradiationfor6-9months,producingmanymicroscopicBCC-likebasaloidlesionsthroughouttheirskin.Moreover,asignificantincreaseinapoptoticnucleicanbeseeninbasaloidnestsafterCUR61414treatmentandnooverttoxicityisobservedintheskinsurroundingthelesions[1].户使⽤本产品发表的科研⽂献•ResearchSquarePreprint.2020Jun.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].WilliamsJA,etal.Identificationofasmallmoleculeinhibitorofthehedgehogsignalingpathway:effectsonbasalcellcarcinoma-likelesions.ProcNatlAcadSciUSA.2003Apr15;100(8):4616-21.Epub2003Apr4.[2].Frank-KamenetskyM,etal.Small-moleculemodulatorsofHedgehogsignaling:identificationandcharacterizationofSmoothenedagonistsandantagonists.JBiol.2002Nov6;1(2):10.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel: