MMG-11-quarterhydrate-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEMMG-11quarterhydrateCat.No.:HY-112146A分⼦式:C₁₅H₁₄O₇.₁/₄H₂O分⼦量:310.78作⽤靶点:Toll-likeReceptor(TLR)作⽤通路:Immunology/Inflammation储存⽅式:Powder-20°C3yearsInsolvent-80°C6months-20°C1month溶解性数据体外实验DMSO:100mg/mL(321.77mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制备储备液1mM3.2177mL16.0886mL32.1771mL5mM0.6435mL3.2177mL6.4354mL10mM0.3218mL1.6089mL3.2177mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。体内实验请根据您的实验动物和给药⽅式选择适当的溶解⽅案。以下溶解⽅案都请先按照InVitro⽅式配制澄的储备液，再依次添加助溶剂：(为保证实验结果的可靠性，澄的储备液可以根据储存条件，适当保存；体内实验的⼯作液，建议您现⽤现配，当天使⽤；以下溶剂前显⽰的百分⽐指该溶剂在您配制终溶液中的体积占⽐；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的⽅式助溶)1.请依序添加每种溶剂：10%DMSO>>40%PEG300>>5%Tween-80>>45%salineSolubility:≥2.08mg/mL(6.69mM);Clearsolution2.请依序添加每种溶剂：10%DMSO>>90%(20%SBE-β-CDinsaline)Solubility:≥2.5mg/mL(8.04mM);Clearsolution3.请依序添加每种溶剂：10%DMSO>>90%cornoil1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemESolubility:≥2.5mg/mL(8.04mM);ClearsolutionBIOLOGICALACTIVITY⽣物活性MMG-11quarterhydrate⼀种有效的选择性⼈TLR2拮抗剂。MMG-11quarterhydrate抑制TLR2/1和TLR2/6信号转导，抑制Pam3CSK4诱导的hTLR2/1，IC50为1.7μM，抑制Pam2CSK4诱导的hTLR2/6反应，IC50为5.7μM[1]。IC50&TargetTLR2体外研究MMG-11neithershowscellulartoxicitynorinterferencewithsignalinginducedbyotherTLRagonists,IL-1βorTNF.MMG-11(0.01-100ꢀµM)showsnocytotoxiceffectsupto100ꢀµMinperipheralbloodmononuclearcells(PBMCs)[1].CellCytotoxicityAssay[1]CellLine:PBMCsConcentration:0.01,1,10,100ꢀµMIncubationTime:Result:Showednocytotoxiceffectsupto100ꢀµM.户使⽤本产品发表的科研⽂献•MolImmunol.2021Feb;130:85-95.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].GrabowskiM,etal.IdentificationofapyrogallolderivativeasapotentandselectivehumanTLR2antagonistbystructure-basedvirtualscreening.BiochemPharmacol.2018Aug;154:148-160.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Te