VH032-PEG5-C6-Cl-HaloPROTAC-2-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEVH032-PEG5-C6-ClCat.No.:HY-112495CASNo.:1799506-06-1Synonyms:HaloPROTAC2分⼦式:C₃₈H₅₉ClN₄O₉S分⼦量:783.41作⽤靶点:E3LigaseLigand-LinkerConjugates作⽤通路:PROTAC储存⽅式:-80°C,protectfromlight,storedundernitrogen溶解性数据体外实验DMSO:270mg/mL(344.65mM;Needultrasonic)Ethanol:100mg/mL(127.65mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制备储备液1mM1.2765mL6.3824mL12.7647mL5mM0.2553mL1.2765mL2.5529mL10mM0.1276mL0.6382mL1.2765mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months(protectfromlight,storedundernitrogen)。-80°C储存时，请在6个⽉内使⽤。体内实验请根据您的实验动物和给药⽅式选择适当的溶解⽅案。以下溶解⽅案都请先按照InVitro⽅式配制澄的储备液，再依次添加助溶剂：(为保证实验结果的可靠性，澄的储备液可以根据储存条件，适当保存；体内实验的⼯作液，建议您现⽤现配，当天使⽤；以下溶剂前显⽰的百分⽐指该溶剂在您配制终溶液中的体积占⽐；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的⽅式助溶)1.请依序添加每种溶剂：10%DMSO>>40%PEG300>>5%Tween-80>>45%salineSolubility:≥5mg/mL(6.38mM);Clearsolution2.请依序添加每种溶剂：10%DMSO>>90%(20%SBE-β-CDinsaline)1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemESolubility:≥5mg/mL(6.38mM);Clearsolution3.请依序添加每种溶剂：10%DMSO>>90%cornoilSolubility:≥5mg/mL(6.38mM);ClearsolutionBIOLOGICALACTIVITY⽣物活性VH032-PEG5-C6-Cl(HaloPROTAC2)由E3配体与21个原⼦相连的复合分⼦，连接⼦的接头为Halogen团。VH032-PEG5-C6-Cl(HaloPROTAC2)包含于VH032的VHL配体和5个单元PEGlinker。VH032-PEG5-C6-Cl能够诱导GFP-HaloTag7降解[1]。IC50&TargetVHL体外研究Treatment(24hour)withVH032-PEG5-C6-Clleadstonearly70%degradationofGFP-Halotag7at2.5μM[1].REFERENCES[1].BuckleyDL,etal.HaloPROTACS:UseofSmallMoleculePROTACstoInduceDegradationofHaloTagFusionProteins.ACSChemBiol.2015Aug21;10(8):1831-7.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;