S-Adenosyl-L-methionine-S-Adenosyl-methionine-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemES-Adenosyl-L-methionineCat.No.:HY-B0617CASNo.:29908-03-0Synonyms:S-Adenosylmethionine;Ademetionine;AdoMet分⼦式:C₁₅H₂₂N₆O₅S分⼦量:398.44作⽤靶点:EndogenousMetabolite作⽤通路:MetabolicEnzyme/Protease储存⽅式:4°C,storedundernitrogen*Insolvent:-80°C,6months;-20°C,1month(storedunder

nitrogen)溶解性数据体外实验DMSO:100mg/mL(250.98mM;Needultrasonic)H2O:≥43mg/mL(107.92mM)*"≥"meanssoluble,butsaturationunknown.MassSolvent1mg5mg10mgConcentration制备储备液1mM2.5098mL12.5489mL25.0979mL5mM0.5020mL2.5098mL5.0196mL10mM0.2510mL1.2549mL2.5098mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month(storedundernitrogen)。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。BIOLOGICALACTIVITY⽣物活性S-Adenosyl-L-methionine(S-Adenosylmethionine)通过蛋氨酸腺苷转移酶的作⽤由蛋氨酸和ATP内性⽣产的，⼀种重的具有⼝服活性的甲供体。S-Adenosyl-L-methionine⼀种具有有效的抗抑郁和减轻疼痛作⽤的膳⾷补充剂，并可⽤于肝病和⾻关节炎的研究。1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemE体外研究S-Adenosyl-L-methionine(Ademetionine)isinvolvedinthreemainmetabolicpathways:1)methylation,astheprincipalsourceofmethylgroupsinthebody;2)transsulfuration,S-Adenosyl-L-methionineformsS-Adenosylhomocysteine(SAH)andthenconvertedtohomocysteine(Hcy)whichcanbeconvertedtocystathioninethentocysteineandthesulfate(SO4)donatedtoothermetabolicintermediates;and3)aminopropylation,asS-Adenosyl-L-methionineplaysanimportantroleinthesynthesisofpolyamineswhichcaneventuallyformandrecyclemethionine[2].InvitrostudiesusinghumanarticularchondrocyteshaveshownS-Adenosyl-L-methionine-inducedincreasesinproteoglycansynthesisandproliferationratesinrabbits[2].体内研究Micelackingmethionineadenosyltransferase1a(Mat1a)havereducedhepaticS-Adenosyl-L-methioninelevelsanddevelopoxidativestress,steatohepatitis,andhepatocellularcarcinoma(HCC).However,injuryandHCCalsooccurifhepaticS-Adenosyl-L-methioninelevelisexcessivechronically.ThusanormalhepaticS-Adenosyl-L-methioninelevelisnecessarytomaintainliverhealthandpreventinjuryandHCC[3].户使⽤本产品发表的科研⽂献•JAgricFoodChem.2021Jul30.•IntImmunopharmacol.2021Mar22;95:107545.•EpigeneticsChromatin.2021Dec4;14(1):52.•ResearchSquarePreprint.2021Jun.•ResearchSquarePreprint.2020Aug.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].GMBressa.S-adenosyl-l-methionine(SAMe)asantidepressant:meta-analysisofclinicalstudies.ActaNeurolScandSuppl.1994;154:7-14.[2].WadieINajm,etal.S-adenosylmethionine(SAMe)versuscelecoxibforthetreatmentofosteoarthritissymptoms:adouble-blindcross-overtrial.[ISRCTN36233495].BMCMusculoskeletDisord.2004Feb26;5:6.[3].ShellyCLu,etal.S-adenosylmethionineinliverhealth,injury,andcancer.PhysiolRev.2012Oct;92(4):1515-42.McePdfHeightCaution:Producthasnotbeenfullyvalidatedform