LL-37-human-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemELL-37,humanCat.No.:HY-P1222CASNo.:154947-66-7分⼦式:C₂₀₅H₃₄₀N₆₀O₅₃分⼦量:4493.26Sequence:Leu-Leu-Gly-Asp-Phe-Phe-Arg-Lys-Ser-Lys-Glu-Lys-Ile-Gly-Ly

s-Glu-Phe-Lys-Arg-Ile-Val-Gln-Arg-Ile-Lys-Asp-Phe-Leu-Arg-A

sn-Leu-Val-Pro-Arg-Thr-Glu-SerSequenceShortening:LLGDFFRKSKEKIGKEFKRIVQRIKDFLRNLVPRTES作⽤靶点:Bacterial作⽤通路:Anti-infection储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性LL-37,human⼀种具有37个残的两亲性组织蛋⽩酶衍⽣的抗肽，具有⼴泛的抗活性。LL-37,human有助于保护⾓膜免受感染，调节伤⼝愈合。体外研究LL-37,human(1-20μg/mL;24h)affectsHCECsmigration[2].LL-37,human(0.0001-5μg/mL;6-24h)affectscytokinesecretioninHCECs[2].LL-37,human(1-100μg/mL;24h)showsdose-dependentlycytotoxictoHCECsatconcentrationsover10μg/mL[2].CellMigrationAssay[2]CellLine:Humancornealepithelialcell(HCEC)Concentration:1,2.5,5,10and20μg/mLIncubationTime:24hoursResult:Dose-dependentlystimulatedHCECmigrationbutshowednoeffectoncellproliferation.CellViabilityAssay[2]CellLine:Humancornealepithelialcell(HCEC)1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemEConcentration:0.0001,0.001,0.01,0.1,0.5,1,and5μg/mLIncubationTime:6and24hoursResult:Dose-dependentlyincreasedIL-8,IL-6,IL-1βandTNF-αsecretionat6and24hoursinHCEC.体内研究LL-37,human(0.4-2.0mg/kg;intratrachealinjectiononce)amelioratesMRSA-inducedpneumoniaofmice[3].AnimalModel:6-8week-oldC57BL/6micewithMRSA-inducedpneumonia[3]Dosage:0.4,0.8,1.2,1.6and2.0mg/kgAdministration:Intratrachealinjection;0.4-2.0mg/kgonceResult:DecreasedIL-6andTNF-αreleasetoattenuatedMRSA-inducedpneumoniaoftestingmice.户使⽤本产品发表的科研⽂献•CommunBiol.2022Jun8;5(1):559.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].HouM,etal.AntimicrobialpeptideLL-37andIDR-1ameliorateMRSApneumoniainvivo.CellPhysiolBiochem.2013;32(3):614-23.[2].DürrUH,etal.LL-37,theonlyhumanmemberofthecathelicidinfamilyofantimicrobialpeptides.BiochimBiophysActa.2006Sep;1758(9):1408-25.[3].HuangLC,etal.Multifunctionalrolesofhumancathelicidin(LL-37)attheocularsurface.InvestOphthalmolVisSci.2006Jun;47(6):2369-80.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearc