2-Deoxy-D-galactose-DataSheet-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemE2-Deoxy-D-galactoseCat.No.:HY-131892CASNo.:1949-89-9分⼦式:C₆H₁₂O₅分⼦量:164.16作⽤靶点:Others作⽤通路:Others储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.溶解性数据体外实验H2O:250mg/mL(1522.90mM;Needultrasonic)Methanol:125mg/mL(761.45mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制备储备液1mM6.0916mL30.4581mL60.9162mL5mM1.2183mL6.0916mL12.1832mL10mM0.6092mL3.0458mL6.0916mLBIOLOGICALACTIVITY⽣物活性2-Deoxy-D-galactose葡萄糖的类似物。2-Deoxy-D-galactose通过抑制糖酵解来抑制肿瘤⽣长。2-Deoxy-D-galactose⼀种⼲扰糖⼤分⼦聚焦化的物质，在各种学习任务中损害记忆巩。2-Deoxy-D-galactose阻碍体内糖蛋⽩集中化。体外研究2-Deoxy-D-galactose(1mM/L;5h)israpidphosphorylationduringthefirst30minanddecreasestoapproximately20%ofthisrateduringthesubsequenthoursinasciteshepatomacells[4].体内研究2-Deoxy-D-galactose(380mg/kg;i.p.;for6times)stronglydecreasescontentsofUMP,UDPG,andUDPgalactoseinratlivers[1].2-Deoxy-D-galactose(2-8μM;intracerebroventricularlyinjection;once)showsPAR1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemEimpairment30minbeforetheacquisitiontrialadoseof4μMand15mindelayafterdo-galadministration[3].AnimalModel:MaleadultWistarratswithpassiveavoidanceresponse(PAR)acquisitiontrial[3]Dosage:2,4and8μMAdministration:Intracerebroventricularlyinjection;2-8μM;onceResult:ExhibitedPARdisruptionatadoseof4μM.REFERENCES[1].KepplerDO,etal.ThetrappingofuridinephosphatesbyD-galactosamine.D-glucosamine,and2-deoxy-D-galactose.Astudyonthemechanismofgalactosaminehepatitis.EurJBiochem.1970Dec;17(2):246-53.[2].KrugM,etal.Theamnesicsubstance2-deoxy-D-galactosesuppressesthemaintenanceofhippocampalLTP.BrainRes.1991Feb1;540(1-2):237-42.[3].LorenziniCG,etal.2-Deoxy-D-galactoseeffectsonpassiveavoidancememorizationintherat.NeurobiolLearnMem.1997Nov;68(3):317-24.[4].SmithDF,KepplerDO.2-Deoxy-D-galactosemetabolisminasciteshepatomacellsresultsinphosphatetrappingandglycolysisinhibition.EurJBiochem.1977Feb15;73(1):83-92.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseo