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March2023
GenerativeAI:
Perspectivesfrom
StanfordHAI
HowdoyouthinkgenerativeAIwillaffectyourfieldandsocietygoingforward?
1
TableofContents
3
4
Introduction
6
UpendingHealthcare,fromPatientCaretoBilling,CurtLanglotz
AI’sGreatInflectionPoint,Fei-FeiLi
ThePotentialsofSyntheticPatients,RussAltman
7
8
10
PoetryWillNotOptimize:CreativityintheAgeofAI,MicheleElam
13
TheNewCambrianEra:‘ScientificExcitement,Anxiety’,PercyLiang15
ACalltoAugment–NotAutomate–Workers,ErikBrynjolfsson
AnAIWindowintoNature,SuryaGanguli
TheNewToolsofDailyLife,JamesLanday
11
GenerativeAIandtheRuleofLaw,DanielE.Ho
16
18
TheReinventionofWork,ChristopherD.Manning
InEducation,a‘DisasterintheMaking’,RobReich20
SolvingInequalitiesintheEducationSystem,PeterNorvig21
Introduction:
ThecurrentwaveofgenerativeAIisasubsetofartificialintelligencethat,
basedonatextualprompt,generatesnovelcontent.ChatGPTmightwrite
anessay,Midjourneycouldcreatebeautifulillustrations,orMusicLMcould
composeajingle.MostmoderngenerativeAIispoweredby
foundation
models
,orAImodelstrainedonbroaddatausingself-supervisionatscale,
thenadaptedtoawiderangeofdownstreamtasks.
Theopportunitiesthesemodelspresentforourlives,ourcommunities,and
oursocietyarevast,asaretheriskstheypose.Whileontheonehand,they
mayseamlesslycomplementhumanlabor,makingusmoreproductiveand
creative,ontheother,theycouldamplifythebiaswealreadyexperienceor
undermineourtrustofinformation.
Webelievethatinterdisciplinarycollaborationisessentialinensuringthese
technologiesbenefitusall.ThefollowingareperspectivesfromStanford
leadersinmedicine,science,engineering,humanities,andthesocialsciences
onhowgenerativeAImightaffecttheirfieldsandourworld.Somestudy
theimpactoftechnologyonsociety,othersstudyhowtobestapplythese
technologiestoadvancetheirfield,andothershavedevelopedthetechnical
principlesofthealgorithmsthatunderliefoundationmodels.
3
4
AI’sGreatInflectionPoint
Fei-FeiLi,SequoiaCapitalProfessorintheComputerScienceDepartment;DenningCo-DirectorofStanfordHAI
540millionyearsago,thenumberofanimalspeciesexplodedinaveryshorttimeperiod.Therearemanytheoriesastowhathappened,butonehascapturedmyattention:thesuddenonsetandensuingevolutionofvision.Today,visualperceptionisamajorsensorysystemandthehumanmindcanrecognizepatternsintheworldandgeneratemodelsorconceptsbasedonthesepatterns.Endowingmachineswiththesecapabilities,generativecapabilities,hasbeenadreamformanygenerationsofAIscientists.Thereisalonghistoryofalgorithmicattemptsatgenerativemodelswithvaryingdegreesofprogress.In1966,researchersatMITdevelopedthe“SummerVisionProject”toeffectivelyconstruct“asignificantpartofthevisualsystem”withtechnology.Thiswasthebeginningofthefieldofcomputervisionandimagegeneration.
Recently,duetotheprofoundandinterconnectedconceptsofdeeplearningandlargedata,weseemtohavereachedaninflectionpointintheabilityofmachinestogeneratelanguage,image,audio,andmore.WhilebuildingAItoseewhathumanscanseewastheinspirationforcomputervision,weshouldnowbelookingbeyondthistobuildingAItoseewhathumanscan’tsee.HowcanweusegenerativeAItoaugmentourvision?Thoughtheexactfigureisdisputed,
deathsduetomedicalerror
intheU.S.isasignificantproblem.GenerativeAImodelscouldassisthealthcareprovidersinseeingpotentialissuesthattheymayhaveotherwisemissed.Furthermore,ifthemistakesareduetominimalexposuretorare
GenerativeAI:PerspectivesfromStanfordHAI
situations,generativeAIcancreatesimulatedversionsofthisraredatatofurthertraintheAImodelsorthehealthcareprovidersthemselves.
Additionally,beforeweevenstartdeveloping
newgenerativetools,weneedtofocusonwhat
peoplewantfromthesetools.Inarecentprojectto
benchmarkroboticstasksbyourlab,beforeeven
startingtheresearch,theprojectteamdidalarge-
scaleuserstudytoaskpeoplehowmuchtheywould
benefitifarobotdidthesecertaintasksforthem.
Thewinningtaskswerethefocusoftheresearch.
Endowingmachineswith
thesecapabilities,generative
capabilities,hasbeena
dreamformanygenerations
ofAIscientists.
Tofullyrealizethesignificantopportunitythat
generativeAIcreates,weneedtoalsoevaluatethe
associatedrisks.JoyBuolamwiniledastudytitled
“GenderShades,”
whichfoundAIsystemsfrequently
failtorecognizewomenandpeopleofcolor.Study
resultswerepublishedin2018.Wecontinuetosee
similarbiasingenerativeAImodels,specificallyfor
underrepresentedpopulations.
5
AI’sGreatInflectionPoint(cont,d)
GenerativeAI:Perspectives
fromStanfordHAI
Theabilitytodeterminewhetheranimagewas
generatedusingAIisalsoessential.Oursocietyisbuilt
ontrustofcitizenshipandinformation.Ifwecannot
easilydeterminewhetheranimageisAIgenerated,
ourtrustofanyinformationwillerode.Inthiscase,we
needtopayspecialattentiontovulnerablepopulations
thatmaybeparticularlysusceptibletoadversarialuses
ofthistechnology.
Theprogressinamachine’scapabilitytogenerate
contentisveryexciting,asisthepotentialtoexplore
AI’sabilitytoseewhathumansarenotable.But
weneedtobeattentivetothewaysinwhichthese
capabilitieswilldisruptoureverydaylives,our
communities,andourroleasworldcitizens.
6
ThePotentialsofSyntheticPatients
GenerativeAI:Perspectives
fromStanfordHAI
RussAltman,KennethFongProfessorintheSchoolofEngineering;ProfessorofBioengineering,ofGenetics,ofMedicine,andofBiomedicalDataScience;AssociateDirectorof
StanfordHAI
Itisoftendifficulttogetlargenumbersofpatientsinclinicaltrialsanditiscrucialtohavearealisticgroupofpatientswhodonotreceiveatherapyinordertocompareoutcomeswiththosewhodo.ThisisoneareawithinbiomedicalresearchwheregenerativeAIoffersgreatopportunities.GenerativeAIcouldmakeclinicaltrialsmoreefficientbycreating“synthetic”controlpatients(i.e.,fakepatients)usingdatafromrealpatientsandtheirunderlyingattributes(tobecomparedwiththepatientswhoreceivethenewtherapy).Itcouldevengeneratesyntheticoutcomestodescribewhathappenstothesepatientsiftheyareuntreated.Biomedicalresearcherscouldthenusetheoutcomesofrealpatientsexposedtoanewdrugwiththesyntheticstatisticaloutcomesforthesyntheticpatients.Thiscouldmaketrialspotentiallysmaller,faster,andlessexpensive,andthusleadtofasterprogressindeliveringnewdrugsanddiagnosticstocliniciansandtheirpatients.
Inthepast,wehaveused“historicalcontrols”whicharepatientswhodidnothavethebenefitofthenewdrugordiagnostic–andcomparedtheiroutcomestopatientswhoreceivedthenewdrugordiagnostic.Syntheticpatientscouldmatchtherealpatientsmorerealistically;theyarecreatedusingknowledgeofcurrentmedications,diagnostictools,andstandardsofpracticethatwerelikelydifferentinthehistoricalsituation.
Inthesettingofmedicaleducation,generativeAIcouldallowustocreatepatientsthatareveryrealisticandcouldallowmedicalstudentstolearnhowtodetect
diseases.Theabilityforgenerativemodelstocreatemanyvariationsonathemecouldallowstudentstoseemultiplecasesofthesamediseaseandlearnthewaysinwhichthesepatientscanvary.Thiscouldgivethemmoreexperienceinseeingadiseaseandprovideanearlyunlimitedsetofcasesforthemtopracticeiftheyfindthatcertaindiseasesaremorechallengingforthemtorecognizeanddiagnose.Thesesamegenerativemodelscouldalsointeractwiththestudentsandgivethempracticeelicitingsignsandsymptomsthroughconversationalinteraction.
Thiscouldmaketrials
potentiallysmaller,faster,and
lessexpensive,andthuslead
tofasterprogressindelivering
newdrugsanddiagnostics.
Withopportunitycomesworry.Ifsyntheticpatientsaregeneratedfromdatathatdoesnotreflectthepopulationofpatientsreceivingthedrug,thepatientsmaybebiased.Moreworrisome,however,isthateventherealpatientsreceivingthedrugwillnotreflectthefullpopulation,andsosyntheticcontrolscouldjustimprovetheuseofthedrugsforasubsetofpatientsandnotall–leadingtoinequity.
Whilegenerativetechnologiescanbeveryusefulin
acceleratingscientificdiscoveryandprogress,care
mustbetakeninselectingthedatausedtogenerate
patientsandthemodelsmustbeexaminedvery
carefullyforbiasesthatmayleadtodisparateimpact.
7
GenerativeAI:PerspectivesfromStanfordHAI
PatientCaretoBilling
UpendingHealthcare,from
CurtLanglotz,ProfessorofRadiology,ofBiomedicalInformaticsResearch,and
ofBiomedicalDataScience;DirectoroftheCenterforArtificialIntelligencein
MedicineandImaging(AIMI);AssociateDirectorofStanfordHAI
Oneofthebenefitsofourhealthcaresystemisthatpatientscanseeavarietyofspecialistphysicianswhoareexpertsinspecificmedicaldisciplines.Thedownsideofoursystemisthatthesespecialistsoftenaren’tacquaintedwiththepatientstheyareseeing.Imagineaworldinwhichaspecialistyouareseeingforthefirsttimehasalreadyreadasuccinctsummaryofyourhealthcareneeds,createdbygenerativeAI.Duringthepatientvisit,achatbotbasedonafoundationmodelcouldserveasthephysician’sassistanttosupportmoreaccuratediagnosisandtailoredtherapyselection.Agenerativemodelcoulddraftaclinicnoteinrealtimebasedonthephysician-patientinteraction,leavingmoretimeforface-to-facediscussion.Inthebackoffice,generativemodelscouldoptimizeclinicschedulingorsimplifygenerationofmedicalcodesforbilling,diseasesurveillance,andautomatedfollow-upreminders.Thesenewcapabilitiescouldimprovetheaccuracyandefficiencyofpatientcarewhileincreasingpatientengagementandadherencetotherapy.
Recentfederallegislationgivespatientstherighttoaccesstheirentiremedicalrecordindigitalform.Asaresult,patientsareincreasinglyencounteringcomplexclinicaldocumentsthatcontainobscuremedicalterms.Whenapatientreturnshomefromaclinicvisit,afoundationmodelcouldgeneratetailoredpatienteducationmaterialsandexplaintheircareplanattheappropriatereadinglevel.
Machinelearningmodelsinmedicinearecritically
dependentonlargemedicaldatasetsthatcontain
examplesofdisease.
Wehaveshown
howdiffusion
models,atypeoffoundationmodel,canbemodified
tocreaterealisticclinicalimagesfromtextprompts.
Ourresultsdemonstratethatsynthetictrainingdata
producedbythesemodelscanaugmentrealtraining
datatoincreasediagnosticaccuracy.Thisformof
syntheticdatacouldhelpsolvemachinelearning
problemsforwhichtrainingdataisscarce,suchasthe
detectionandtreatmentofuncommondiseases.
Duringthepatientvisit,a
chatbot…couldserveasthe
physician’sassistanttosupport
moreaccuratediagnosisand
tailoredtherapyselection.
Finally,generativeAI’swell-reportedchallenges
withfactualcorrectnessareparticularlyproblematicinmedicine,whereinaccuraciescancauseseriousharm.Recentproblemsinmedicineincludeincorrectdifferentialdiagnosisandinvalidscientificcitations.Weareworkingto
improvethefactualcorrectness
ofmedicalexplanationsfromthesemodelssotheycanachieveanaccuracythatissuitableforsafeclinicaluse.
8
AnAIWindowintoNature
SuryaGanguli,AssociateProfessorofAppliedPhysics;AssociateDirectorof
StanfordHAI
Scientificideasfromthestudyofnatureitself,intheformofnonequilibriumthermodynamicsandthereversaloftheflowoftime,leadtothecreationatStanfordofthefirst
diffusionmodel
,akeykerneloftechnologythatformsthebasisofmanysuccessfulAIgenerativemodelstoday.Now,inavirtuouscycle,AIgenerativemodelsarewellpoisedtodeliverconsiderableinsightsintonatureitself,acrossbiological,physical,andmentalrealms,withbroadimplicationsforsolvingkeysocietalproblems.
Forexample,
generativemodelsofproteins
canallowustoefficientlyexplorethespaceofcomplexthree-dimensionalproteinstructures,therebyaidinginthesearchforproteinswithnovelandusefulfunctions,includingnewefficaciousmedicines.Generative
AIisstartingtobeexploredinthe
quantumrealm
,enablingustoefficientlymodelstronglycorrelatedstatesofelectrons,withthepotentialofadvancingourunderstandingof
materialsscience
and
quantum
chemistry
.Theseadvancescouldinturnleadtothecreationofnewmaterialsandcatalyststhatcouldplayaroleinefficientenergycaptureandstorage.Simplegenerativemodeling,intertwinedwithclassicalnumericalsolvers,hasalsomadekeyadvancesinaccurateandfastlargescale
fluid
mechanicalsimulations
,whichwhenscaledup,couldaidinclimatemodelingandweatherforecasting,therebycontributingtoadeeperunderstandingofourchangingclimateanditsramifications.
GenerativeAI:PerspectivesfromStanfordHAI
Inabeautifulrecursion,thegenerativeAImodelsthat
wehavecreatedcanalsoactasscientificwindows,
notonlyintothephysicalworldbutalsointoour
own
minds
.Forthefirsttime,wehaveAIsystems
thatcanmodelhigh-levelcognitivephenomena
likenaturallanguageandimageunderstanding.ManyneuroscientistsandcognitivescientistshavecomparedtheneuralrepresentationsofbothdeepnetworksandAIgenerativemodelstoneurobiologicalrepresentationsinhumansandanimals,oftenfindingstrikingsimilaritiesacrossmanybrainareas.Examplesincludethe
retina
,the
ventralvisualstream
,
motor
cortex
,
entorhinalcortex
fornavigation,
cortical
language
areas,andneuralgeometriesunderlying
few
shotconceptlearning
.Theoftensimilarstructureofartificialandbiologicalsolutionstogenerativetaskssuggeststheremaybesomecommonprinciplesgoverninghowintelligentsystems,whetherbiologicalorartificial,modelandgeneratecomplexdata.
AIgenerativemodelsarewell
poisedtodeliverconsiderable
insightsintonatureitself,
acrossbiological,physical,
andmentalrealms,with
broadimplicationsforsolving
keysocietalproblems.
9
AnAIWindowintoNature(cont,d)
GenerativeAI:Perspectives
fromStanfordHAI
AnexceedinglyinterestingandprofoundquestionarisesintheforthcomingageofscientificcollaborationbetweenhumansandAIsystemsastheyworktogetherinalooptoanalyzeourcomplexbiological,physical,andmentalworlds:WhatdoesitmeanforahumantoderiveaninterpretableunderstandingofacomplexsystemwhenanAIprovidesasubstantialpartofthatunderstandingthroughpredictivemodels?Issuesregarding
explainableAI
willlikelyrisetotheforewhenafundamentallyhumanscientificendeavor,namelyunderstandingourworld,ispartiallyachievedthroughtheuseofAI.HumanscientistswillnotbecontentwithuninterpretableAI-generatedpredictionsalone.Theywilldesirehumaninterpretableunderstanding,inaddition.
Finally,todreamevenbigger,whiletoday’sgenerativeAIhasaccesstoimmenseglobalscaletrainingdataspanningimages,text,andvideofromtheinternet,itdoesnothavedirectaccesstoourownthoughts,intheformofneuralactivitypatterns.However,thisneednotalwaysbethecase,givenremarkablenewneuroscientificcapacitiestorecordmanyneuronsfromthebrainsofanimalswhiletheyviewimages,aswellastoperformMEG,EEG,andfMRIfromhumansastheyexperiencetheworldthroughrichmultimodalsensoryexperiences.Suchcombinedneuralandreal-worlddatacouldthenpotentiallybeusedtotrainnextgenerationmultimodalfoundationmodelsthatnotonlyunderstandthephysicalworldbutalsounderstandthedirectimpactthephysicalworldhasonourmentalworld,intermsofelicitedneuralactivitypatterns.Whatmightsuchhybridbiological-artificialintelligencesteachusaboutourselves?
Overall,thefutureofgenerativeAIasawindowinto
nature,andtheuseofthiswindowtosolvesocietal
problems,isfullofpromise.Wecertainlydolivein
interestingtimes.
10
TheNewToolsofDailyLife
JamesLanday,AnandRajaramanandVenkyHarinarayanProfessorintheSchoolofEngineeringandProfessorofComputerScience;ViceDirectorofStanfordHAI
GenerativeAI:Perspectives
fromStanfordHAI
Asweallknow,AIistakingtheworldbystorm.Wewillbegintoseemanynewtoolsthataugmentourabilitiesinprofessionalandpersonalactivitiesandworkflows.Imagineasmarttutorthatisalwayspatientandunderstandsthelevelofknowledgethestudenthasatanypointintimeonanysubject.Thesetutorswillnotreplaceteachers,butinsteadwillaugmentthestudentlearningexperience–givingstudentsamorepersonalizedinteraction,focusinginareaswheretheymightbeweaker.
Indesign,pictureatoolthatassistsaprofessionaldesignerbyriffingofftheirinitialdesignideasandhelpingthemexploremoreideasorfillindetailsontheirinitialideas.GenerativeAIwillalsounleashlanguage-basedinterfaces,whetherwrittenorspoken,asamorecommonwayofinteractingwithoureverydaycomputingsystems,especiallywhenonthegoorwhenoureyesandhandsarebusy.ImagineanAlexa,Siri,orGoogleAssistantthatcanactuallyunderstandwhatyouaretryingtodoratherthanjustansweringsimplequeriesabouttheweatherormusic.
WhilegenerativeAIcreatesmanyexcitingopportunities,weknowfrompastAIdeploymentstherearerisks.In2016,anAI-basedsoftwaretoolusedacrossthecountrytopredictifacriminaldefendantwaslikelytoreoffendinthefuturewasshowntobebiasedagainstBlackAmericans.Weneedtoensurewearedesigningthesetoolstogetthemostpositiveoutcomes.Todothis,weneedtodeeplydesignand
analyzethesesystemsattheuser,thecommunity,andsocietallevels.Attheuserlevel,weneedtocreatenewdesignsthataugmentpeoplebyaccountingfortheirexistingworkflowsandcognitiveabilities.Butwecan’tjustdesignfortheuser.Weneedtoconsiderthecommunitythatthesystemimpacts:thefamilies,theinfrastructure,andthelocaleconomy.But,eventhatisnotenough,weneedtoanalyzetheimpactstosocietyatlarge.Weneedtobeabletoforecastwhathappensifthesystembecomesubiquitousandfromthestartdesignmitigationsforpossiblenegativeimpacts.
Changesthatareunderpinned
bygenerativeAIareonlynow
startingtobeimaginedby
designersandtechnologists.
Ouruserinterfacetocomputinghasbeenfairlystatic
overthelast30years.Inthenext5–10years,we
willseearevolutioninhuman-computerinteraction.
ChangesthatareunderpinnedbygenerativeAIare
onlynowstartingtobeimaginedbydesignersand
technologists.Nowisthetimetoensurethatweare
criticallythinkingabouttheuser,thecommunity,and
thesocietalimpacts.
11
PoetryWillNotOptimize:CreativityintheAgeofAI
MicheleElam,WilliamRobertsonCoeProfessorintheSchoolofHumanitiesandSciencesandProfessorofEnglish;AssociateDirectorofStanfordHAI
In2018,theprofessionalartworldwasupendedwhentherenownedChristie’sauctionhouse
soldanAI-
augmentedwork
,“PortraitofEdmondBelamy,”forthewildlyunexpectedsumof$435,000.Thatsale,whichcamewiththetacitimprimaturoftheestablishedartcommunity,generatedmuchgnashingofteethandhand-wringingintheartssectoroverwhatartificialintelligencemeansforthecreativeindustry.
Sincethen,thegeniehaslongfleditslamp:GenerativeAIhasenabledvisualartofeveryknowngenreaswellas
AI-augmentedpoetry
,fiction,
filmscripts
,
music
and
musicals
,
symphonies
,AI-curatedarthistories,andmuchmore.
ThefurorovertheChristie’ssalemaynowseemquaint–itoccurredbeforeDALL-E,LensaAI,ChatGPT,Bing,tonamejustafew–butitheraldedmanyoftoday’sincreasinglyferociousdebatesoverthenatureofcreativityandthefutureofworkforthecreativeindustry.Itanticipatedthecurrenthornet’snestofethical,political,andaestheticconcernsthatgenerativeAIposesforthearts.
Someoftheseconcernshavebeenproductive:GenerativeAIhasencouragedmanyofthosewhoselivelihoods,andinmanycasestheiridentities,dependontheirartisticproductionstoconsideranew–andinnewways–perennialquestionsaboutfoundationalaestheticnormsandvalue:Whatdo
GenerativeAI:PerspectivesfromStanfordHAI
weidentifyas“art”?Whatcountsas“good”art?Isartistrydefinedbyhumanagencyorautomation?Justwhoorwhatcanmake“art”?Andwhodecides?GenerativeAIraisesimportant,thornyquestionsaboutauthenticity,economicvaluation,provenance,creatorcompensation,andcopyright.(TheGettyImageslawsuitagainstStableDiffusionisjustthetipofaniceberg.)Italso,arguably,normalizesextractiveandexploitativeapproachestocreatorsandtheirwork;amplifiesbiasesofeverykind;exacerbatesalreadyurgenteducationalandnationalsecurityconcernsarounddeepfakesandplagiarism,especiallyintheabsenceofcongressionalregulation.
Shouldtheprinciplesof
efficiency,speed,and
so-calledblessingsofscale
applysounequivocallyto
creativeprocesses?Afterall,
poetrydoesnotoptimize.
Perhapsthemostpressingconcern,intermsofnationalsecurity,isthatgenerativeAImighttakeadvantageofthefactthattheartshavealwaysshaped–forgoodorill–thecivicimagination,thatstories,films,plays,imagesshapeourperceptionofourselves,ofourphysicalandsocialrealities.OneofthemostfamousdisagreementsbetweenPlatoandhisstudentAristotlewasoverthepotentiallydangerouspowerof
12
PoetryWillNotOptimize:CreativityintheAgeofAI(contd)
GenerativeAI:Perspectives
fromStanfordHAI
poesytoinfluencebeliefsandworldviews.Thispoweriswhyfascistregimesfirstdoawaywiththeartistsandintellectuals:becausetheyholdswayoverourmindsandthusouractions.
SomeclaimthatgenerativeAIisdemocratizingaccesstocreativeexpressiontothosetraditionallybarredfromitbylackofstatusorwealth.Butdoclaimsto“democratization”and“access”function,ineffect,asindustrycoverfor
rushingacommercialapplication
“intothewild”
(i.e.,tothepublic)withoutthetime-intensiveworkofensuringethicalguardrails?
IsAIsimplyaneutralifpowerfulassistivetoolforthearts–akintopen,paintbrush,orphotography?Isit“
blitzscaling
”creativity,orinEmadMostaque’s
choice
description
,relievingour“creativelyconstipated”worldwithAItechnologiesthatcanhaveusall
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